date_range Duration: from 01 January 2016 to 31 December 2018 (36 months)
euro 77,440.00 EUR

Of National scope.

Researchers

Foto de Gonzalo
Gonzalo
Jiménez Osés
Leader

Publications related to the project

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2019

  1. Efficient and irreversible antibody–cysteine bioconjugation using carbonylacrylic reagents

    Nature Protocols

  2. Elusive Dehydroalanine Derivatives with Enhanced Reactivity

    ChemBioChem

2018

  1. Tn Antigen Mimics by Ring-Opening of Chiral Cyclic Sulfamidates with Carbohydrate C1- S- and C1- O-Nucleophiles

    Journal of Organic Chemistry

  2. Oxygen by Carbon Replacement at the Glycosidic Linkage Modulates the Sugar Conformation in Tn Antigen Mimics

    ACS Omega

  3. Cell-Penetrating Peptides Containing Fluorescent d-Cysteines

    Chemistry - A European Journal

  4. Chemo- and Regioselective Lysine Modification on Native Proteins

    Journal of the American Chemical Society

2017

  1. Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells

    Angewandte Chemie International

  2. A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst

    Journal of the American Chemical Society

  3. Metal-Free [2 + 2]-Photocycloaddition of (Z)-4-Aryliden-5(4H)-Oxazolones as Straightforward Synthesis of 1,3-Diaminotruxillic Acid Precursors: Synthetic Scope and Mechanistic Studies

    ACS Sustainable Chemistry and Engineering

  4. Multiple Mechanisms for the Thermal Decomposition of Metallaisoxazolin-5-ones from Computational Investigations

    Journal of Organic Chemistry

  5. 1,3-Dipolar Cycloaddition Reactions of Low-Valent Rhodium and Iridium Complexes with Arylnitrile N-Oxides

    Journal of Organic Chemistry

  6. Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation

    Journal of the American Chemical Society

2016

  1. A Minimal, Unstrained S-Allyl Handle for Pre-Targeting Diels–Alder Bioorthogonal Labeling in Live Cells

    Angewandte Chemie International

  2. Tn Antigen Mimics Based on sp2-Iminosugars with Affinity for an anti-MUC1 Antibody

    Organic Letters

  3. Bifunctional Chiral Dehydroalanines for Peptide Coupling and Stereoselective S-Michael Addition

    Organic Letters

  4. Finding the Right Candidate for the Right Position: A Fast NMR-Assisted Combinatorial Method for Optimizing Nucleic Acids Binders

    Journal of the American Chemical Society

  5. A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2

    Nature Chemical Biology

  6. Computations Reveal That Electron-Withdrawing Leaving Groups Facilitate Intramolecular Conjugate Displacement Reactions by Negative Hyperconjugation

    Journal of Organic Chemistry

  7. Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents

    Nature Communications