Rational design of a Tn antigen mimic

  1. Corzana, F. 1
  2. Busto, J.H. 1
  3. Marcelo, F. 3
  4. García De Luis, M. 1
  5. Asensio, J.L. 5
  6. Martín-Santamaría, S. 4
  7. Sáenz, Y. 2
  8. Torres, C. 12
  9. Jiménez-Barbero, J. 3
  10. Avenoza, A. 1
  11. Peregrina, J.M. 1
  1. 1 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    GRID grid.119021.a

  2. 2 Centro de Investigación Biomédica de La Rioja
    info

    Centro de Investigación Biomédica de La Rioja

    Logroño, España

    GRID grid.428104.b

  3. 3 Centro de Investigaciones Biológicas
    info

    Centro de Investigaciones Biológicas

    Madrid, España

    GRID grid.418281.6

  4. 4 Universidad CEU San Pablo
    info

    Universidad CEU San Pablo

    Madrid, España

    GRID grid.8461.b

  5. 5 Instituto de Química Orgánica General
    info

    Instituto de Química Orgánica General

    Madrid, España

    GRID grid.419121.e

Journal:
Chemical Communications

ISSN: 1359-7345

Year of publication: 2011

Volume: 47

Issue: 18

Pages: 5319-5321

Type: Article

Export: RIS
DOI: 10.1039/c1cc10192g PMID: 21451866 SCOPUS: 2-s2.0-79954580576 WoS: 000289689600063 GOOGLE SCHOLAR

Metrics

Cited by

  • Scopus Cited by: 18 (12-06-2021)

Journal Citation Reports

  • Year 2011
  • Journal Impact Factor: 6.169
  • Best Quartile: Q1
  • Area: CHEMISTRY, MULTIDISCIPLINARY Quartile: Q1 Rank in area: 19/154 (Ranking edition: SCIE)

SCImago Journal Rank

  • Year 2011
  • SJR Journal Impact: 2.889
  • Best Quartile: Q1
  • Area: Catalysis Quartile: Q1 Rank in area: 8/45
  • Area: Ceramics and Composites Quartile: Q1 Rank in area: 4/128
  • Area: Chemistry (miscellaneous) Quartile: Q1 Rank in area: 22/457
  • Area: Electronic, Optical and Magnetic Materials Quartile: Q1 Rank in area: 15/335
  • Area: Materials Chemistry Quartile: Q1 Rank in area: 7/293
  • Area: Metals and Alloys Quartile: Q1 Rank in area: 4/192
  • Area: Surfaces, Coatings and Films Quartile: Q1 Rank in area: 3/167

CiteScore

  • Year 2011
  • CiteScore of the Journal : 7.9
  • Area: Metals and Alloys Percentile: 98
  • Area: Surfaces, Coatings and Films Percentile: 97
  • Area: Ceramics and Composites Percentile: 96
  • Area: Materials Chemistry Percentile: 96
  • Area: Chemistry (all) Percentile: 94
  • Area: Electronic, Optical and Magnetic Materials Percentile: 93
  • Area: Medicine (all) Percentile: 90
  • Area: Catalysis Percentile: 81

Abstract

A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural lectin as for the natural Tn and retains the bioactive conformation observed in the Tn-containing glycopeptides with anti-MUC1 antibodies. © 2011 The Royal Society of Chemistry.