Rational design of a Tn antigen mimic
- Corzana, F. 1
- Busto, J.H. 1
- Marcelo, F. 3
- García De Luis, M. 1
- Asensio, J.L. 5
- Martín-Santamaría, S. 4
- Sáenz, Y. 2
- Torres, C. 12
- Jiménez-Barbero, J. 3
- Avenoza, A. 1
- Peregrina, J.M. 1
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1
Universidad de La Rioja
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2
Centro de Investigación Biomédica de La Rioja
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3
Centro de Investigaciones Biológicas
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4
Universidad CEU San Pablo
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5
Instituto de Química Orgánica General
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ISSN: 1359-7345
Year of publication: 2011
Volume: 47
Issue: 18
Pages: 5319-5321
Type: Article
More publications in: Chemical Communications
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Abstract
A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural lectin as for the natural Tn and retains the bioactive conformation observed in the Tn-containing glycopeptides with anti-MUC1 antibodies. © 2011 The Royal Society of Chemistry.