Rational design of a Tn antigen mimic

  1. Corzana, F. 1
  2. Busto, J.H. 1
  3. Marcelo, F. 3
  4. García De Luis, M. 1
  5. Asensio, J.L. 5
  6. Martín-Santamaría, S. 4
  7. Sáenz, Y. 2
  8. Torres, C. 12
  9. Jiménez-Barbero, J. 3
  10. Avenoza, A. 1
  11. Peregrina, J.M. 1
  1. 1 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  2. 2 Centro de Investigación Biomédica de La Rioja
    info

    Centro de Investigación Biomédica de La Rioja

    Logroño, España

    ROR https://ror.org/03vfjzd38

  3. 3 Centro de Investigaciones Biológicas
    info

    Centro de Investigaciones Biológicas

    Madrid, España

    ROR https://ror.org/04advdf21

  4. 4 Universidad CEU San Pablo
    info

    Universidad CEU San Pablo

    Madrid, España

    ROR https://ror.org/00tvate34

  5. 5 Instituto de Química Orgánica General
    info

    Instituto de Química Orgánica General

    Madrid, España

    ROR https://ror.org/05e0q7s59

Revue:
Chemical Communications

ISSN: 1359-7345

Année de publication: 2011

Volumen: 47

Número: 18

Pages: 5319-5321

Type: Article

DOI: 10.1039/C1CC10192G PMID: 21451866 SCOPUS: 2-s2.0-79954580576 WoS: WOS:000289689600063 GOOGLE SCHOLAR

D'autres publications dans: Chemical Communications

Résumé

A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural lectin as for the natural Tn and retains the bioactive conformation observed in the Tn-containing glycopeptides with anti-MUC1 antibodies. © 2011 The Royal Society of Chemistry.