Computational chemistry: a useful tool in the fight against hepatitis C

  1. González, M. 1
  2. Rodríguez, A. 1
  3. Martínez, R. 2
  1. 1 Universitat de Barcelona
    info

    Universitat de Barcelona

    Barcelona, España

    ROR https://ror.org/021018s57

  2. 2 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

Revista:
EUROPEAN INFECTIOUS DISEASE

ISSN: 1755-1137

Año de publicación: 2011

Volumen: 5

Número: 1

Páginas: 38-43

Tipo: Artículo

SCOPUS: 2-s2.0-84857547403 GOOGLE SCHOLAR

Otras publicaciones en: EUROPEAN INFECTIOUS DISEASE

Resumen

This article discusses the main recent contributions of computational chemistry to the development of hepatitis C virus (HCV) drugs, with a focus on the HCV NS3/NS4A protease inhibitors and the challenges and complexities involved in their development. Furthermore, new strategies resulting from a detailed knowledge of the protease reaction mechanism will be discussed. © Touch Briefings 2011.