Computational chemistry: a useful tool in the fight against hepatitis C

  1. González, M. 1
  2. Rodríguez, A. 1
  3. Martínez, R. 2
  1. 1 Universitat de Barcelona
    info

    Universitat de Barcelona

    Barcelona, España

    ROR https://ror.org/021018s57

  2. 2 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

Journal:
EUROPEAN INFECTIOUS DISEASE

ISSN: 1755-1137

Year of publication: 2011

Volume: 5

Issue: 1

Pages: 38-43

Type: Article

SCOPUS: 2-s2.0-84857547403 GOOGLE SCHOLAR

More publications in: EUROPEAN INFECTIOUS DISEASE

Abstract

This article discusses the main recent contributions of computational chemistry to the development of hepatitis C virus (HCV) drugs, with a focus on the HCV NS3/NS4A protease inhibitors and the challenges and complexities involved in their development. Furthermore, new strategies resulting from a detailed knowledge of the protease reaction mechanism will be discussed. © Touch Briefings 2011.