Computational chemistry: a useful tool in the fight against hepatitis C
- González, M. 1
- Rodríguez, A. 1
- Martínez, R. 2
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1
Universitat de Barcelona
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2
Universidad de La Rioja
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ISSN: 1755-1137
Année de publication: 2011
Volumen: 5
Número: 1
Pages: 38-43
Type: Article
D'autres publications dans: EUROPEAN INFECTIOUS DISEASE
Résumé
This article discusses the main recent contributions of computational chemistry to the development of hepatitis C virus (HCV) drugs, with a focus on the HCV NS3/NS4A protease inhibitors and the challenges and complexities involved in their development. Furthermore, new strategies resulting from a detailed knowledge of the protease reaction mechanism will be discussed. © Touch Briefings 2011.