Synthesis of 2-amino-1,3-diols incorporating the cyclobutane ring
- Pérez-Fernández, M. 1
- Avenoza, A. 1
- Busto, J.H. 1
- Peregrina, J.M. 1
- Rodríguez, F. 1
-
1
Universidad de La Rioja
info
ISSN: 0040-4020
Ano de publicación: 2008
Volume: 64
Número: 38
Páxinas: 9088-9092
Tipo: Artigo
Outras publicacións en: Tetrahedron
Proxectos relacionados
Resumo
The synthesis of free and protected 2-amino-1,3-diols with threoninol substructure that incorporate a conformational restriction defined by the cyclobutane ring is reported. The key step in the synthesis of these target compounds, namely cis- and trans-c 4-threoninols, is the addition of methylmagnesium bromide to a cyclobutanone derivative. The selectivity of the reaction is modulated by the solvent. © 2008 Elsevier Ltd. All rights reserved.