New Syntheses of enantiopure 2-methyl isoserines
- Avenoza, A. 1
- Busto, J.H. 1
- Corzana, F. 1
- Jiménez-Osés, G. 1
- París, M. 1
- Peregrina, J.M. 1
- Sucunza, D. 1
- Zurbano, M.M. 1
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1
Universidad de La Rioja
info
ISSN: 0957-4166
Argitalpen urtea: 2004
Alea: 15
Zenbakia: 1
Orrialdeak: 131-137
Mota: Artikulua
Beste argitalpen batzuk: Tetrahedron: Asymmetry
Laburpena
Herein we describe the synthesis of the two enantiomerically pure 3-amino-2-hydroxy-2-methylpropionic acids - (S)- and (R)-α-methyl isoserines - starting from the chiral diols (S)- and (R)-2,3-dihydroxy-N- methoxy-2,N-dimethylpropionamides, respectively, which were obtained by Sharpless asymmetric dihydroxylation (AD) of the olefin N-methoxy-2,N- dimethylacrylamide with AD-mix α or β as chiral catalytic ligands. © 2003 Elsevier Ltd. All rights reserved.