Synthesis, activity and theoretical study of ABT-418 analogues

  1. Avenoza, A. 1
  2. Busto, J.H. 1
  3. Cativiela, C. 2
  4. Dordal, A. 3
  5. Frigola, J. 3
  6. Peregrina, J.M. 1
  1. 1 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  2. 2 Instituto de Nanociencia y Materiales de Aragón
    info

    Instituto de Nanociencia y Materiales de Aragón

    Zaragoza, España

    ROR https://ror.org/031n2c920

  3. 3 Laboratorios Dr. Esteve S.A., 08041 Barcelona, Spain
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Revue:
Tetrahedron

ISSN: 0040-4020

Année de publication: 2002

Volumen: 58

Número: 22

Pages: 4505-4511

Type: Article

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DOI: 10.1016/S0040-4020(02)00388-5 SCOPUS: 2-s2.0-0037182005 WoS: WOS:000175892400018 GOOGLE SCHOLAR

D'autres publications dans: Tetrahedron

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Résumé

This report shows the synthesis and biological evaluation of two new conformationally restricted ABT-418 analogues. This restriction is introduced by the incorporation of the 7-azabicyclo[2.2.1]heptane skeleton. Furthermore, we report here a high-level quantum mechanical study of their conformations in the gas phase. © 2002 Published by Elsevier Science Ltd.