Synthesis, activity and theoretical study of ABT-418 analogues
- Avenoza, A. 1
- Busto, J.H. 1
- Cativiela, C. 2
- Dordal, A. 3
- Frigola, J. 3
- Peregrina, J.M. 1
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1
Universidad de La Rioja
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2
Instituto de Nanociencia y Materiales de Aragón
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- 3 Laboratorios Dr. Esteve S.A., 08041 Barcelona, Spain
ISSN: 0040-4020
Year of publication: 2002
Volume: 58
Issue: 22
Pages: 4505-4511
Type: Article
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Abstract
This report shows the synthesis and biological evaluation of two new conformationally restricted ABT-418 analogues. This restriction is introduced by the incorporation of the 7-azabicyclo[2.2.1]heptane skeleton. Furthermore, we report here a high-level quantum mechanical study of their conformations in the gas phase. © 2002 Published by Elsevier Science Ltd.