Principles of mucin structure: Implications for the rational design of cancer vaccines derived from MUC1-glycopeptides

  1. Martínez-Sáez, N. 12
  2. Peregrina, J.M. 1
  3. Corzana, F. 1
  1. 1 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  2. 2 Utrecht University
    info

    Utrecht University

    Utrecht, Holanda

    ROR https://ror.org/04pp8hn57

Revista:
Chemical Society Reviews

ISSN: 0306-0012

Año de publicación: 2017

Volumen: 46

Número: 23

Páginas: 7154-7175

Tipo: Artículo

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DOI: 10.1039/C6CS00858E SCOPUS: 2-s2.0-85035309252 WoS: WOS:000417020300004 GOOGLE SCHOLAR

Otras publicaciones en: Chemical Society Reviews

Objetivos de desarrollo sostenible

Resumen

Cancer is currently one of the world's most serious public health problems. Significant efforts are being made to develop new strategies that can eradicate tumours selectively without detrimental effects to healthy cells. One promising approach is focused on the design of vaccines that contain partially glycosylated mucins in their formulation. Although some of these vaccines are in clinical trials, a lack of knowledge about the molecular basis that governs the antigen presentation, and the interactions between antigens and the elicited antibodies has limited their success thus far. This review focuses on the most significant milestones achieved to date in the conformational analysis of tumour-associated MUC1 derivatives both in solution and bound to antibodies. The effect that the carbohydrate scaffold has on the peptide backbone structure and the role of the sugar in molecular recognition by antibodies are emphasised. The outcomes summarised in this review may be a useful guide to develop new antigens for the design of cancer vaccines in the near future. © 2017 The Royal Society of Chemistry.