Diseño estructural de glicopeptidos de tipo mucina que incorporan miméticos del antigeno TN para desarrollar biomarcadores y vacunas contra el cáncer.

Financed by Ministerio de Economía y Competitividad
Duration of the 01 of January of 2016 to 31 of December of 2018

Researchers

Publications related to the project

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2016

  1. Síntesis de a/ß-péptidos híbridos tioglicosilados mediante apertura de sulfamidatos cíclicos

    Iván García Gonzalez

  2. Reacciones de metátesis e hidrotiolación como herramientas sintéticas para la obtención de compuestos con interés biológico

    Víctor Rojas Ocáriz

  3. Mucin Architecture behind the Immune Response: Design and Evaluation of an Antitumor Vaccine Derived from an Unnatural MUC1 Fragment

    Chemical Science

  4. Design of α-S-Neoglycopeptides Derived from MUC1 with a Flexible and Solvent-Exposed Sugar Moiety

    Journal of Organic Chemistry

  5. Tn Antigen Mimics Based on sp2-Iminosugars with Affinity for an anti-MUC1 Antibody

    Organic Letters

  6. Bifunctional Chiral Dehydroalanines for Peptide Coupling and Stereoselective S-Michael Addition

    Organic Letters

  7. Conformationally-locked C-glycosides: tuning aglycone interactions for optimal chaperone behaviour in Gaucher fibroblasts

    Organic and Biomolecular Chemistry

  8. A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2

    Nature Chemical Biology

  9. Chondroitin Sulfate Tetrasaccharides: Synthesis, Three-Dimensional Structure and Interaction with Midkine

    Chemistry - A European Journal

  10. Quillaja saponin variants with central glycosidic linkage modifications exhibit distinct conformations and adjuvant activities

    Chemical Science

  11. Finding the Right Candidate for the Right Position: A Fast NMR-Assisted Combinatorial Method for Optimizing Nucleic Acids Binders

    Journal of the American Chemical Society

  12. Unraveling the Conformational Landscape of Ligand Binding to Glucose/Galactose-Binding Protein by Paramagnetic NMR and MD Simulations

    ACS chemical biology

  13. Diastereomeric Glycosyl Sulfoxides Display Different Recognition Features versus E. coli β-Galactosidase

    European Journal of Organic Chemistry

  14. Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents

    Nature Communications

  15. Unveiling (−)-Englerin A as a Modulator of L-Type Calcium Channels

    Angewandte Chemie International