A Biomimetic Approach to Lanthionines

  1. Aydillo, C. 1
  2. Avenoza, A. 1
  3. Busto, J.H. 1
  4. Jiménez-Osés, G. 12
  5. Peregrina, J.M. 1
  6. Zurbano, M.M. 1
  1. 1 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  2. 2 University of California Los Angeles
    info

    University of California Los Angeles

    Los Ángeles, Estados Unidos

    ROR https://ror.org/046rm7j60

Revista:
Organic Letters

ISSN: 1523-7060

Año de publicación: 2012

Volumen: 14

Número: 1

Páginas: 334-337

Tipo: Artículo

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DOI: 10.1021/OL203068S SCOPUS: 2-s2.0-84855499525 WoS: WOS:000298828500086 GOOGLE SCHOLAR

Otras publicaciones en: Organic Letters

Resumen

The asymmetric sulfa-Michael additions of appropriately protected l- and d-cysteine derivatives to new chiral dehydroamino acid derivatives have been developed as key steps in the synthesis of biologically important cysteine derivatives, such as lanthionine (Lan) and β-methyllanthionine (MeLan), which are unusual bis-α-amino acids found in the emerging lantibiotics such as nisin. © 2011 American Chemical Society.