A Biomimetic Approach to Lanthionines
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1
Universidad de La Rioja
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2
University of California Los Angeles
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ISSN: 1523-7060
Year of publication: 2012
Volume: 14
Issue: 1
Pages: 334-337
Type: Article
More publications in: Organic Letters
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Abstract
The asymmetric sulfa-Michael additions of appropriately protected l- and d-cysteine derivatives to new chiral dehydroamino acid derivatives have been developed as key steps in the synthesis of biologically important cysteine derivatives, such as lanthionine (Lan) and β-methyllanthionine (MeLan), which are unusual bis-α-amino acids found in the emerging lantibiotics such as nisin. © 2011 American Chemical Society.