Jesús Manuel
Peregrina García
CATEDRÁTICO DE UNIVERSIDAD
![Foto de Jesús Manuel](/img/uploaded/E4715E8C7A5CC349B4FF512D02965805.jpg)
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Universidad de Zaragoza
Zaragoza, EspañaPublikationen in Zusammenarbeit mit Forschern von Universidad de Zaragoza (24)
2024
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Detection of Tumor-Associated Autoantibodies in the Sera of Pancreatic Cancer Patients Using Engineered MUC1 Glycopeptide Nanoparticle Probes
Angewandte Chemie - International Edition
2023
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Methyl-to-Ethyl Replacement Makes the Difference: Structure-Guided Design of a New Cancer Vaccine Based on a Tn An-gen Surrogate
VI RSEQ Chemical Biology Group Meeting - ChemBio VI
2020
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Synthesis, conformational analysis and: In vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment
Chemical Science, Vol. 11, Núm. 15, pp. 3996-4006
2019
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Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage
Journal of the American Chemical Society, Vol. 141, Núm. 9, pp. 4063-4072
2018
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The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies inpatients with cancer
29th International Carbohydrate Symposium - ICS2018
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Water Sculpts the Distinctive Shapes and Dynamics of the Tumor-Associated Carbohydrate Tn Antigens: Implications for Their Molecular Recognition
Journal of the American Chemical Society, Vol. 140, Núm. 31, pp. 9952-9960
2017
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The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer
Journal of the American Chemical Society, Vol. 139, Núm. 50, pp. 18255-18261
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The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences
Nature Communications, Vol. 8, Núm. 1
2016
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Bifunctional Chiral Dehydroalanines for Peptide Coupling and Stereoselective S-Michael Addition
Organic Letters, Vol. 18, Núm. 12, pp. 2796-2799
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Design of α-S-Neoglycopeptides Derived from MUC1 with a Flexible and Solvent-Exposed Sugar Moiety
Journal of Organic Chemistry, Vol. 81, Núm. 14, pp. 5929-5941
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Mucin Architecture behind the Immune Response: Design and Evaluation of an Antitumor Vaccine Derived from an Unnatural MUC1 Fragment
Chemical Science, Vol. 7, Núm. 3, pp. 2294
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Tn Antigen Mimics Based on sp2-Iminosugars with Affinity for an anti-MUC1 Antibody
Organic Letters, Vol. 18, Núm. 15, pp. 3890-3893
2015
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Deciphering the Non-Equivalence of Serine and Threonine O-glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti-MUC1 Antibody
Angewandte Chemie International, Vol. 54, Núm. 34, pp. 9830
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Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation
Nature Communications, Vol. 6, pp. 1-12
2014
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Combined structural snapshots and metadynamics reveal a substrate-guided SNi-type reaction for polypeptide GalNAc transferaseT2
XI Carbohydrate Symposium
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Serine versus Threonine Glycosylation witha-O-GalNAc: Unexpected Selectivity in Their Molecular Recognition with Lectins
Chemistry - A European Journal, Vol. 20, Núm. 39, pp. 12616-12627
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Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase 2
Angewandte Chemie International, Vol. 53, Núm. 31, pp. 8206-8210
2002
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Preparation and Synthetic Applications of (S)- and (R)-N-Boc-N,O-Isopropylidene-alfa-methylserinals
Targets in Heterocyclic Systems (ITALIAN SOCIETY OF CHEMISTRY), pp. 231-244
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Tandem Diels-Alder Cycloaddition/Rearrangement: a Method for the Synthesis of a 2,5,6-Trisubstituted Biphenyl
Afinidad: Revista de química teórica y aplicada, Vol. 59, Núm. 500, pp. 431-434
1999
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Preparation and synthetic applications of (S)- and (R)-N-Boc-N,O-isopropylidene-alfa-methylserinals: asymmetric synthesis of (S)- and (R)-2-amino-2-methylbutanoic acids (Iva)
Journal of Organic Chemistry, Vol. 64, Núm. 22, pp. 8220-8225