Gonçalo
Bernardes
Publicaciones en las que colabora con Gonçalo Bernardes (33)
2023
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Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules
ACS Central Science, Vol. 9, Núm. 5, pp. 892-904
2022
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Platform for Orthogonal N-Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents
Journal of the American Chemical Society, Vol. 144, Núm. 23, pp. 10396-10406
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Selective Inhibition of Bruton’s Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors
ACS Pharmacology and Translational Science, Vol. 5, Núm. 11, pp. 1156-1168
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Single Mutation on Trastuzumab Modulates the Stability of Antibody-Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry
Journal of the American Chemical Society, Vol. 144, Núm. 12, pp. 5284-5294
2021
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Accelerating Reaction Rates of Biomolecules by Using Shear Stress in Artificial Capillary Systems
Journal of the American Chemical Society, Vol. 143, Núm. 40, pp. 16401-16410
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Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression
ACS Central Science, Vol. 7, Núm. 5, pp. 868-881
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Arylethynyltrifluoroborate Dienophiles for on Demand Activation of IEDDA Reactions
Bioconjugate Chemistry, Vol. 32, Núm. 8, pp. 1812-1822
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Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation
Organic Letters, Vol. 23, Núm. 21, pp. 8580-8584
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Dichloro Butenediamides as Irreversible Site-Selective Protein Conjugation Reagent
Angewandte Chemie - International Edition, Vol. 60, Núm. 44, pp. 23750-23755
2020
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Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects
Cell Metabolism, Vol. 31, Núm. 6, pp. 1120-1135.e7
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Precise protein conjugation technology for the construction of homogenous glycovaccines
Drug Discovery Today: Technologies, Vol. 38, pp. 69-75
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Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation
Angewandte Chemie - International Edition, Vol. 59, Núm. 15, pp. 6196-6200
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Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors
RSC Chemical Biology, Vol. 1, Núm. 4, pp. 251-262
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Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody
Chemical Communications, Vol. 56, Núm. 96, pp. 15137-15140
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Synthesis, conformational analysis and: In vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment
Chemical Science, Vol. 11, Núm. 15, pp. 3996-4006
2019
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A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia
Leukemia, Vol. 33, Núm. 9, pp. 2155-2168
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Design and implementation of gold-nanoparticle formulations as MUC1-directed cancer vaccines
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
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Efficient and irreversible antibody–cysteine bioconjugation using carbonylacrylic reagents
Nature Protocols, Vol. 14, Núm. 1, pp. 86-99
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Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation
Angewandte Chemie - International Edition, Vol. 58, Núm. 20, pp. 6640-6644
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Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage
Journal of the American Chemical Society, Vol. 141, Núm. 9, pp. 4063-4072