Publications by the researcher in collaboration with Gonçalo Bernardes (33)

2023

  1. Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules

    ACS Central Science, Vol. 9, Núm. 5, pp. 892-904

2022

  1. Platform for Orthogonal N-Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents

    Journal of the American Chemical Society, Vol. 144, Núm. 23, pp. 10396-10406

  2. Selective Inhibition of Bruton’s Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors

    ACS Pharmacology and Translational Science, Vol. 5, Núm. 11, pp. 1156-1168

  3. Single Mutation on Trastuzumab Modulates the Stability of Antibody-Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry

    Journal of the American Chemical Society, Vol. 144, Núm. 12, pp. 5284-5294

2021

  1. Accelerating Reaction Rates of Biomolecules by Using Shear Stress in Artificial Capillary Systems

    Journal of the American Chemical Society, Vol. 143, Núm. 40, pp. 16401-16410

  2. Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression

    ACS Central Science, Vol. 7, Núm. 5, pp. 868-881

  3. Arylethynyltrifluoroborate Dienophiles for on Demand Activation of IEDDA Reactions

    Bioconjugate Chemistry, Vol. 32, Núm. 8, pp. 1812-1822

  4. Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation

    Organic Letters, Vol. 23, Núm. 21, pp. 8580-8584

  5. Dichloro Butenediamides as Irreversible Site-Selective Protein Conjugation Reagent

    Angewandte Chemie - International Edition, Vol. 60, Núm. 44, pp. 23750-23755

2020

  1. Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects

    Cell Metabolism, Vol. 31, Núm. 6, pp. 1120-1135.e7

  2. Precise protein conjugation technology for the construction of homogenous glycovaccines

    Drug Discovery Today: Technologies, Vol. 38, pp. 69-75

  3. Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation

    Angewandte Chemie - International Edition, Vol. 59, Núm. 15, pp. 6196-6200

  4. Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors

    RSC Chemical Biology, Vol. 1, Núm. 4, pp. 251-262

  5. Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody

    Chemical Communications, Vol. 56, Núm. 96, pp. 15137-15140

  6. Synthesis, conformational analysis and: In vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment

    Chemical Science, Vol. 11, Núm. 15, pp. 3996-4006

2019

  1. A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia

    Leukemia, Vol. 33, Núm. 9, pp. 2155-2168

  2. Design and implementation of gold-nanoparticle formulations as MUC1-directed cancer vaccines

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

  3. Efficient and irreversible antibody–cysteine bioconjugation using carbonylacrylic reagents

    Nature Protocols, Vol. 14, Núm. 1, pp. 86-99

  4. Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation

    Angewandte Chemie - International Edition, Vol. 58, Núm. 20, pp. 6640-6644

  5. Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage

    Journal of the American Chemical Society, Vol. 141, Núm. 9, pp. 4063-4072