Publicaciones en colaboración con investigadores/as de Universidad de Zaragoza (29)

2023

  1. Methyl-to-Ethyl Replacement Makes the Difference: Structure-Guided Design of a New Cancer Vaccine Based on a Tn An-gen Surrogate

    VI RSEQ Chemical Biology Group Meeting - ChemBio VI

2022

  1. Aplicación de la Realidad Aumentada a la Visualización de Estructuras y de Procesos en Química Orgánica

    Aplicación de la Realidad Aumentada a la Visualización de Estructuras y de Procesos en Química Orgánica

2020

  1. Synthesis, conformational analysis and: In vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment

    Chemical Science, Vol. 11, Núm. 15, pp. 3996-4006

2019

  1. Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage

    Journal of the American Chemical Society, Vol. 141, Núm. 9, pp. 4063-4072

2018

  1. The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies inpatients with cancer

    29th International Carbohydrate Symposium - ICS2018

  2. Water Sculpts the Distinctive Shapes and Dynamics of the Tumor-Associated Carbohydrate Tn Antigens: Implications for Their Molecular Recognition

    Journal of the American Chemical Society, Vol. 140, Núm. 31, pp. 9952-9960

2017

  1. The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer

    Journal of the American Chemical Society, Vol. 139, Núm. 50, pp. 18255-18261

  2. The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences

    Nature Communications, Vol. 8, Núm. 1

2016

  1. Bifunctional Chiral Dehydroalanines for Peptide Coupling and Stereoselective S-Michael Addition

    Organic Letters, Vol. 18, Núm. 12, pp. 2796-2799

  2. Design of α-S-Neoglycopeptides Derived from MUC1 with a Flexible and Solvent-Exposed Sugar Moiety

    Journal of Organic Chemistry, Vol. 81, Núm. 14, pp. 5929-5941

  3. Mucin Architecture behind the Immune Response: Design and Evaluation of an Antitumor Vaccine Derived from an Unnatural MUC1 Fragment

    Chemical Science, Vol. 7, Núm. 3, pp. 2294

  4. Tn Antigen Mimics Based on sp2-Iminosugars with Affinity for an anti-MUC1 Antibody

    Organic Letters, Vol. 18, Núm. 15, pp. 3890-3893

2015

  1. Deciphering the Non-Equivalence of Serine and Threonine O-glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti-MUC1 Antibody

    Angewandte Chemie International, Vol. 54, Núm. 34, pp. 9830

  2. Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation

    Nature Communications, Vol. 6, pp. 1-12

2014

  1. Combined structural snapshots and metadynamics reveal a substrate-guided SNi-type reaction for polypeptide GalNAc transferaseT2

    XI Carbohydrate Symposium

  2. Serine versus Threonine Glycosylation witha-O-GalNAc: Unexpected Selectivity in Their Molecular Recognition with Lectins

    Chemistry - A European Journal, Vol. 20, Núm. 39, pp. 12616-12627

  3. Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase 2

    Angewandte Chemie International, Vol. 53, Núm. 31, pp. 8206-8210

2002

  1. Preparation and Synthetic Applications of (S)- and (R)-N-Boc-N,O-Isopropylidene-alfa-methylserinals

    Targets in Heterocyclic Systems (ITALIAN SOCIETY OF CHEMISTRY), pp. 231-244

  2. Tandem Diels-Alder Cycloaddition/Rearrangement: a Method for the Synthesis of a 2,5,6-Trisubstituted Biphenyl

    Afinidad: Revista de química teórica y aplicada, Vol. 59, Núm. 500, pp. 431-434

1999

  1. Preparation and synthetic applications of (S)- and (R)-N-Boc-N,O-isopropylidene-alfa-methylserinals: asymmetric synthesis of (S)- and (R)-2-amino-2-methylbutanoic acids (Iva)

    Journal of Organic Chemistry, Vol. 64, Núm. 22, pp. 8220-8225