Biological Study of New Cationic Bis-Difluorophenylpyridinate Ir(III) Complexes

  1. G. Millán 2
  2. M. Nieddu 2
  3. C. Ezquerro 2
  4. J. R. Berenguer 2
  5. E. Lalinde 2
  6. I. P. Lopez 1
  7. I. M. Larráyoz 1
  8. José G. Pichel 1
  1. 1 Centro de Investigación Biomédica de La Rioja (CIBIR)
  2. 2 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

Actas:
XXXVIII Reunión Bienal de la Real Sociedad Española de Química - RSEQ 2022 (Abstracts book)

Editorial: Real Sociedad Española de Química

ISBN: 978-84-09-42159-6

Año de publicación: 2022

Páginas: 349

Congreso: XXXVIII Reunión Bienal de la Real Sociedad Española de Química (RSEQ Granada 2022) 27-30 de junio de 2022

Tipo: Aportación congreso

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Resumen

Nowadays, the desire to find new compounds with multifunctional properties, whose purpose is helping in the early diagnosis and treatment of some illness, has opened numerous investigations. In particular, in cancer treatments, the research of new theranostic complexes is exponentially growing with the aim of reduce the side effects, obtaining higher specify than classical drugs like cisplatinum. Furthermore, new treatments like photodynamic therapy (PDT) can be an alternative to the classical chemotherapy. In PDT, the irradiation with visible light of a photosensitizer induces the formation of reactive oxygen species or 1O2, which damage the nearby cells.[1]In this line, it is well known the antineoplastic activity of certain cyclometalated Ir(III) complexes. Moreover, these compounds are good candidates to substitute some organic molecules, whose life-times are shorts, to be used in bioimaging and biosensing, due their stability and photophysical properties, showing high quantum yields and long life times. Also, these properties can be easily modulated by modification of the ancillary ligands.In this communication we present the excellent theranostic properties of complex [Ir(dfppy)2(dbbpy)]Cl 2a (dfppy = difluorophenylpyridine; dbbpy = N,N-dibutyl-2,2’-bipyridine-4,4’-dicarboxamide), as well as the influence on the biological properties, and their use in PDT, of the functionalization of both the cyclometalated groups {[Ir(C^N)2(dbbpy)]+X- (X = Cl- or PF6-; C^N is dfppy-CHO (2b) or dfppy-COOH (2c)]} and the ancillary chelating bpy-based ligands {[Ir(dfppy-CHO)2(dobpy)]Cl 3b and [Ir(dfppy)2(3,3´-H2dcbpy)]PF6 4a}.

Referencias bibliográficas

  • [1]. Zafon, E.; Echevarría, I.; Barrabés, S.; Manzano, B. R.; Jalón, F. A.; Rodríguez, A. M.; Massaguer, A.; Espino, G. J. D. T. Dalton Trans. 2022, 51 (1), 111-128.