Biological Study of New Cationic Bis-Difluorophenylpyridinate Ir(III) Complexes
- G. Millán 2
- M. Nieddu 2
- C. Ezquerro 2
- J. R. Berenguer 2
- E. Lalinde 2
- I. P. Lopez 1
- I. M. Larráyoz 1
- José G. Pichel 1
- 1 Centro de Investigación Biomédica de La Rioja (CIBIR)
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2
Universidad de La Rioja
info
Éditorial: Real Sociedad Española de Química
ISBN: 978-84-09-42159-6
Année de publication: 2022
Pages: 349
Congreso: XXXVIII Reunión Bienal de la Real Sociedad Española de Química (RSEQ Granada 2022) 27-30 de junio de 2022
Type: Communication dans un congrès
beta Ver similares en nube de resultadosRésumé
Nowadays, the desire to find new compounds with multifunctional properties, whose purpose is helping in the early diagnosis and treatment of some illness, has opened numerous investigations. In particular, in cancer treatments, the research of new theranostic complexes is exponentially growing with the aim of reduce the side effects, obtaining higher specify than classical drugs like cisplatinum. Furthermore, new treatments like photodynamic therapy (PDT) can be an alternative to the classical chemotherapy. In PDT, the irradiation with visible light of a photosensitizer induces the formation of reactive oxygen species or 1O2, which damage the nearby cells.[1]In this line, it is well known the antineoplastic activity of certain cyclometalated Ir(III) complexes. Moreover, these compounds are good candidates to substitute some organic molecules, whose life-times are shorts, to be used in bioimaging and biosensing, due their stability and photophysical properties, showing high quantum yields and long life times. Also, these properties can be easily modulated by modification of the ancillary ligands.In this communication we present the excellent theranostic properties of complex [Ir(dfppy)2(dbbpy)]Cl 2a (dfppy = difluorophenylpyridine; dbbpy = N,N-dibutyl-2,2’-bipyridine-4,4’-dicarboxamide), as well as the influence on the biological properties, and their use in PDT, of the functionalization of both the cyclometalated groups {[Ir(C^N)2(dbbpy)]+X- (X = Cl- or PF6-; C^N is dfppy-CHO (2b) or dfppy-COOH (2c)]} and the ancillary chelating bpy-based ligands {[Ir(dfppy-CHO)2(dobpy)]Cl 3b and [Ir(dfppy)2(3,3´-H2dcbpy)]PF6 4a}.
Références bibliographiques
- [1]. Zafon, E.; Echevarría, I.; Barrabés, S.; Manzano, B. R.; Jalón, F. A.; Rodríguez, A. M.; Massaguer, A.; Espino, G. J. D. T. Dalton Trans. 2022, 51 (1), 111-128.