Caracterización de bacterias ácido-lácticas con propiedades antimicrobianas e inmunomoduladoras y su investigación aplicada en sanidad animal

Resum

The crosstalk between the microbiota and its host represents a study model that can be replicated for the development of novel tools to control certain diseases. Wild animals harbor a microbiota that overhangs for the greater diversity and functionality. Hence, it is presented as a source of beneficial microorganisms that can be industrially exploited to obtain bioactive compounds. This doctoral thesis describes the procedures for the isolation and characterization of bacteria with antimicrobial and immunomodulatory properties from wild boar microbiota, as well as the criteria for selecting candidates to be used for the design of a functional feed. Similarly, the great novelty of this Industrial Doctorate thesis supposes concluding with its applied research through the elaboration of a postbiotic product. The development of the postbiotic includes several validation studies under experimental conditions and its ratification in real situations in animal health, both in wildlife and livestock. The method developed in this Industrial Doctorate thesis has had a significant impact on the activity of INGULADOS. The company has increased its competitiveness within its sector, since the launch of a range of postbiotic products has favoured the creation of a new line of work and a new job profile and the technology transfer has resulted in the application for two invention patents. The studies of this doctoral thesis have increased the available knowledge on the interaction between the host and its microbiota and show great future prospects for the use of innovative elements in Animal Health and Production.