A Domino Michael/Dieckmann Process as an Entry to alpha-(Hydroxymethyl)glutamic Acid

  1. Aydillo, C. 1
  2. Jiménez-Osés, G. 2
  3. Avenoza, A. 1
  4. Busto, J.H. 1
  5. Peregrina, J.M. 1
  6. Zurbano, M.M. 1
  1. 1 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  2. 2 University of California Los Angeles
    info

    University of California Los Angeles

    Los Ángeles, Estados Unidos

    ROR https://ror.org/046rm7j60

Revista:
Journal of Organic Chemistry

ISSN: 0022-3263

Año de publicación: 2011

Volumen: 76

Número: 17

Páginas: 6990-6996

Tipo: Artículo

DOI: 10.1021/JO201067N SCOPUS: 2-s2.0-80052154759 WoS: WOS:000294242900002 GOOGLE SCHOLAR

Otras publicaciones en: Journal of Organic Chemistry

Resumen

A domino process that involves a Michael-type addition followed by a Dieckmann reaction mediated by the participation of the cyclic carbamate group is the key step in the synthesis of both enantiomers of α-(hydroxymethyl) glutamic acid (HMG). © 2011 American C emical Society.