Structural-based Design of Highly Crowded Ribostamycin/Kanamycin Hybrids as a new Family of Antibiotics

  1. Revuelta, J. 1
  2. Vacas, T. 1
  3. Corzana, F. 2
  4. Gonzalez, C. 3
  5. Bastida, A. 1
  6. Asensio, J.L. 1
  1. 1 Instituto de Química Orgánica General
    info

    Instituto de Química Orgánica General

    Madrid, España

    ROR https://ror.org/05e0q7s59

  2. 2 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  3. 3 Instituto de Química Física Rocasolano
    info

    Instituto de Química Física Rocasolano

    Madrid, España

    ROR https://ror.org/03xk60j79

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Revue:
Chemistry - A European Journal

ISSN: 0947-6539

Année de publication: 2010

Volumen: 16

Número: 10

Pages: 2986-2991

Type: Article

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DOI: 10.1002/CHEM.200903003 PMID: 20162651 SCOPUS: 2-s2.0-77649222388 WoS: WOS:000275943400004 GOOGLE SCHOLAR

D'autres publications dans: Chemistry - A European Journal

Résumé

Sugar sugar! The synthesis and evaluation of ribostamycin/kanamycin hybrids incorporating a highly crowded trisubstituted aminocyclitol unit that should provide maximum complementation with the RNA receptor are reported (see picture). Analysis shows that the existing conflicts between the different sugar rings can be significantly alleviated by a simple chemical modification, leading to an improvement in activity. (Figure Presented) © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.