Structural-based Design of Highly Crowded Ribostamycin/Kanamycin Hybrids as a new Family of Antibiotics
- Revuelta, J. 1
- Vacas, T. 1
- Corzana, F. 2
- Gonzalez, C. 3
- Bastida, A. 1
- Asensio, J.L. 1
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1
Instituto de Química Orgánica General
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2
Universidad de La Rioja
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3
Instituto de Química Física Rocasolano
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ISSN: 0947-6539
Datum der Publikation: 2010
Ausgabe: 16
Nummer: 10
Seiten: 2986-2991
Art: Artikel
Andere Publikationen in: Chemistry - A European Journal
Zusammenfassung
Sugar sugar! The synthesis and evaluation of ribostamycin/kanamycin hybrids incorporating a highly crowded trisubstituted aminocyclitol unit that should provide maximum complementation with the RNA receptor are reported (see picture). Analysis shows that the existing conflicts between the different sugar rings can be significantly alleviated by a simple chemical modification, leading to an improvement in activity. (Figure Presented) © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.