Symptomatic and functional outcome in youth at ultra-high risk for psychosis: A longitudinal study.

  1. Lemos-Giráldez, S. 12
  2. Vallina-Fernández, O. 3
  3. Fernández-Iglesias, P. 23
  4. Vallejo-Seco, G. 2
  5. Fonseca-Pedrero, E. 12
  6. Paíno-Piñeiro, M. 12
  7. Sierra-Baigrie, S. 2
  8. García-Pelayo, P. 3
  9. Pedrejón-Molino, C. 3
  10. Alonso-Bada, S. 3
  11. Gutiérrez-Pérez, A. 3
  12. Ortega-Ferrández, J.A. 3
  1. 1 Centro de Investigacion Biomedica en Red de Salud Mental
    info

    Centro de Investigacion Biomedica en Red de Salud Mental

    Madrid, España

    ROR https://ror.org/009byq155

  2. 2 Universidad de Oviedo
    info

    Universidad de Oviedo

    Oviedo, España

    ROR https://ror.org/006gksa02

  3. 3 Hospital Sierrallana
    info

    Hospital Sierrallana

    Torrelavega, España

    ROR https://ror.org/01b2c5015

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Revista:
Schizophrenia Research

ISSN: 0920-9964

Año de publicación: 2009

Volumen: 115

Número: 2-3

Páginas: 121-129

Tipo: Artículo

DOI: 10.1016/J.SCHRES.2009.09.011 PMID: 19786339 SCOPUS: 2-s2.0-71649094109 GOOGLE SCHOLAR

Otras publicaciones en: Schizophrenia Research

Resumen

The current report assesses the clinical, functioning and demographic data of a cohort enrolled in the P3 prevention program for psychosis; a Spanish National Health System and Ministry of Science funded program. Comparisons are made between those individuals who had converted to psychosis and those who had not at 3 years after an average of 24 treatment sessions. Subjects included 61 participants meeting Structured Interview for Prodromal Syndromes criteria, with ages ranging from 17 to 31, and all meeting criteria for ultra-high risk of psychosis. Prospective follow-up data are reported for patients re-evaluated at 1 and 3 years. At 1-year follow-up, the conversion rate to psychosis was 18%, but increased to 23% at 3-year follow-up. The converted sample was older than the non-converted sample and more likely to have higher ratings on subsyndromal psychotic (positive and disorganized), negative and general symptoms, and lower levels of functioning at baseline assessment. Analyses of change over time indicated a clear clinical improvement in both clinically stable patients and in those who showed a transient psychotic state over time. No gender differences in symptom or functioning levels at the three follow-up time points were found; however, the interactions among conversion × gender × SOPS total score × time points significantly reflect that the growth profiles of the four groups (no conversion males, no conversion females, conversion males and conversion females) in the SOPS total score are not parallel and that, consequently, the four groups involved different patterns of change over time, males experiencing faster and longer deterioration when psychotic symptoms arise. © 2009 Elsevier B.V. All rights reserved.