Engineering O-glycosylation Points in Non-extended Peptides: Implications for the Molecular Recognition of Short Tumor-associated Glycopeptides

  1. Corzana, F. 3
  2. Busto, J.H. 3
  3. Marcelo, F. 1
  4. Garcíadeluis, M. 3
  5. Asensio, J.L. 4
  6. Martín-Santamaría, S. 2
  7. Jiménez-Barbero, J. 1
  8. Avenoza, A. 3
  9. Peregrina, J.M. 3
  1. 1 Centro de Investigaciones Biológicas
    info

    Centro de Investigaciones Biológicas

    Madrid, España

    GRID grid.418281.6

  2. 2 Universidad CEU San Pablo
    info

    Universidad CEU San Pablo

    Madrid, España

    GRID grid.8461.b

  3. 3 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    GRID grid.119021.a

  4. 4 Instituto de Química Orgánica General
    info

    Instituto de Química Orgánica General

    Madrid, España

    GRID grid.419121.e

Journal:
Chemistry - A European Journal

ISSN: 0947-6539

Year of publication: 2011

Volume: 17

Issue: 11

Pages: 3105-3110

Type: Article

Export: RIS
DOI: 10.1002/chem.201003124 SCOPUS: 2-s2.0-79952126046 WoS: 000288098800011 GOOGLE SCHOLAR

Metrics

Cited by

  • Scopus Cited by: 17 (12-06-2021)

Journal Citation Reports

  • Year 2011
  • Journal Impact Factor: 5.925
  • Best Quartile: Q1
  • Area: CHEMISTRY, MULTIDISCIPLINARY Quartile: Q1 Rank in area: 20/154 (Ranking edition: SCIE)

SCImago Journal Rank

  • Year 2011
  • SJR Journal Impact: 2.902
  • Best Quartile: Q1
  • Area: Catalysis Quartile: - Rank in area: 7/45
  • Area: Organic Chemistry Quartile: - Rank in area: 8/182
  • Area: Chemistry (miscellaneous) Quartile: Q1 Rank in area: 21/457

CiteScore

  • Year 2011
  • CiteScore of the Journal : 8.8
  • Area: Chemistry (all) Percentile: 95
  • Area: Medicine (all) Percentile: 92

Abstract

The ties that bind: The incorporation of non-natural residues in the peptide backbone allows the design of O-glycosylation points in helical segments. This strategy could help to modulate the binding properties between glycopeptides and their protein receptors, such as lectins and antibodies. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.