An Efficient Synthesis of Quinazolines: a Theoretical and Experimental Study on the Photochemistry of Oxime Derivatives
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Universidad de La Rioja
info
ISSN: 0040-4020
Argitalpen urtea: 2010
Alea: 66
Zenbakia: 25
Orrialdeak: 4469-4473
Mota: Artikulua
Beste argitalpen batzuk: Tetrahedron
Lotura duten proiektuak
Laburpena
A new photochemical method for the preparation of quinazolines (2) through irradiation of [2-(methyleneamino)phenyl]methanone oximes (1) is reported. The photoreaction has been studied in depth by experimental, theoretical and photochemical methods. A six-electron electrocyclic ring closure mechanism, followed by water loss, is proposed and rationalized to explain the formation of quinazolines (2). © 2010 Elsevier Ltd. All rights reserved.