An Efficient Synthesis of Quinazolines: a Theoretical and Experimental Study on the Photochemistry of Oxime Derivatives
-
1
Universidad de La Rioja
info
ISSN: 0040-4020
Year of publication: 2010
Volume: 66
Issue: 25
Pages: 4469-4473
Type: Article
More publications in: Tetrahedron
Related Projects
Abstract
A new photochemical method for the preparation of quinazolines (2) through irradiation of [2-(methyleneamino)phenyl]methanone oximes (1) is reported. The photoreaction has been studied in depth by experimental, theoretical and photochemical methods. A six-electron electrocyclic ring closure mechanism, followed by water loss, is proposed and rationalized to explain the formation of quinazolines (2). © 2010 Elsevier Ltd. All rights reserved.