ESBL, plasmidic AmpC, and associated quinolone resistance determinants in coliforms isolated from hospital effluent: First report of qnrB2, qnrB9, qnrB19, and blaCMY-4 in Algeria

  1. Anssour, L. 2
  2. Messai, Y. 2
  3. Derkaoui, M. 2
  4. Alouache, S. 23
  5. Estepa, V. 1
  6. Somalo, S. 1
  7. Torres, C. 1
  8. Bakour, R. 2
  1. 1 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  2. 2 University of Sciences and Technology Houari Boumediene
    info

    University of Sciences and Technology Houari Boumediene

    Argel, Argelia

    ROR https://ror.org/02kb89c09

  3. 3 École Nationale Supérieure des Sciences de la Mer et de l'Aménagement du Littoral
    info

    École Nationale Supérieure des Sciences de la Mer et de l'Aménagement du Littoral

    Argel, Argelia

    ROR https://ror.org/046eg6x37

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Revista:
Journal of Chemotherapy

ISSN: 1120-009X

Ano de publicación: 2014

Volume: 26

Número: 2

Páxinas: 74-79

Tipo: Artigo

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DOI: 10.1179/1973947813Y.0000000115 SCOPUS: 2-s2.0-84895808282 WoS: WOS:000335054800003 GOOGLE SCHOLAR

Outras publicacións en: Journal of Chemotherapy

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2013/00001/001

Resumo

The characterization of extended-spectrum beta-lactamases, plasmidic AmpC (pAmpC), and associated plasmid-mediated quinolone resistance (PMQR) determinants in cefotaxime-resistant coliforms isolated from hospital effluent in Algiers showed bla CTX-M genes in 89%, bla TEM-1 in 79•8%, and pAmpC genes (bla CIT) in 2•7% isolates. Association of IS Ecp1B with bla CTX-M was found in all CTX-M+ isolates, and 97•2% harboured class 1 integrons. Sequencing showed bla CTX-M-15, bla CTX-M-3, and bla CMY-4 genes. bla CTX-M-3 and bla CTX-M-15 were located in Inc L/M conjugative plasmids. The PMQR determinants identified were qnrB1, qnrB2, qnrB9, qnrB19, qnrS2, and aac(6')-Ib-cr. qnrB2, qnrB9, qnrB19, and bla CMY-4are described for the first time in Algeria and qnrB19 for the first time in non-clinical environments. This study highlights the major potential role of hospital effluents as providers of resistance genes to natural environments. © 2014 Edizioni Scientifiche per l'Informazione su Farmaci e Terapia.