Rational Design and Synthesis of Efficient Sunscreens To Boost the Solar Protection Factor
- Losantos, R. 1
- Funes-Ardoiz, I. 1
- Aguilera, J. 2
- Herrera-Ceballos, E. 2
- García-Iriepa, C. 13
- Campos, P.J. 1
- Sampedro, D. 1
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1
Universidad de La Rioja
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2
Universidad de Málaga
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3
Universidad de Alcalá
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ISSN: 1433-7851
Año de publicación: 2017
Volumen: 56
Número: 10
Páginas: 2632-2635
Tipo: Artículo
beta Ver similares en nube de resultadosOtras publicaciones en: Angewandte Chemie International
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Resumen
Skin cancer incidence has been increasing in the last decades, but most of the commercial formulations used as sunscreens are designed to protect only against solar erythema. Many of the active components present in sunscreens show critical weaknesses, such as low stability and toxicity. Thus, the development of more efficient components is an urgent health necessity and an attractive industrial target. We have rationally designed core moieties with increased photoprotective capacities and a new energy dissipation mechanism. Using these scaffolds, we have synthesized a series of compounds with tunable properties suitable for their use in sunscreens, and enhanced properties in terms of stability, light energy dissipation, and toxicity. Moreover, some representative compounds were included in final sunscreen formulations and a relevant solar protection factor boost was measured. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim