Rational Design and Synthesis of Efficient Sunscreens To Boost the Solar Protection Factor

  1. Losantos, R. 1
  2. Funes-Ardoiz, I. 1
  3. Aguilera, J. 2
  4. Herrera-Ceballos, E. 2
  5. García-Iriepa, C. 13
  6. Campos, P.J. 1
  7. Sampedro, D. 1
  1. 1 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  2. 2 Universidad de Málaga
    info

    Universidad de Málaga

    Málaga, España

    ROR https://ror.org/036b2ww28

  3. 3 Universidad de Alcalá
    info

    Universidad de Alcalá

    Alcalá de Henares, España

    ROR https://ror.org/04pmn0e78

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Revista:
Angewandte Chemie International

ISSN: 1433-7851

Ano de publicación: 2017

Volume: 56

Número: 10

Páxinas: 2632-2635

Tipo: Artigo

DOI: 10.1002/ANIE.201611627 SCOPUS: 2-s2.0-85011319767 WoS: WOS:000395183600012 GOOGLE SCHOLAR

Outras publicacións en: Angewandte Chemie International

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Sistemas fotoactivos: aplicaciones biológicas y de almacenamiento de energía. Photoactive systems: biological applications and energy storage.

2015/00065/001

Resumo

Skin cancer incidence has been increasing in the last decades, but most of the commercial formulations used as sunscreens are designed to protect only against solar erythema. Many of the active components present in sunscreens show critical weaknesses, such as low stability and toxicity. Thus, the development of more efficient components is an urgent health necessity and an attractive industrial target. We have rationally designed core moieties with increased photoprotective capacities and a new energy dissipation mechanism. Using these scaffolds, we have synthesized a series of compounds with tunable properties suitable for their use in sunscreens, and enhanced properties in terms of stability, light energy dissipation, and toxicity. Moreover, some representative compounds were included in final sunscreen formulations and a relevant solar protection factor boost was measured. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim