Public health risks of enterobacterial isolates producing extended-spectrum β-lactamases or AmpC β-lactamases in food and food-producing animals: An EU perspective of epidemiology, analytical methods, risk factors, and control options

  1. Liebana, E. 11
  2. Carattoli, A. 3
  3. Coque, T.M. 13
  4. Hasman, H. 5
  5. Magiorakos, A.-P. 6
  6. Mevius, D. 24
  7. Peixe, L. 8
  8. Poirel, L. 12
  9. Schuepbach-Regula, G. 14
  10. Torneke, K. 10
  11. Torren-Edo, J. 7
  12. Torres, C. 1
  13. Threlfall, J. 9
  1. 1 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  2. 2 Department of Bacteriology and Transmissible Spongiform Encephalopathies, Central Veterinary Institute, Lelystad, Netherlands
  3. 3 Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy
  4. 4 Utrecht University
    info

    Utrecht University

    Utrecht, Holanda

    ROR https://ror.org/04pp8hn57

  5. 5 Technical University of Denmark
    info

    Technical University of Denmark

    Kongens Lyngby, Dinamarca

    ROR https://ror.org/04qtj9h94

  6. 6 European Centre for Disease Prevention and Control
    info

    European Centre for Disease Prevention and Control

    Estocolmo, Suecia

    ROR https://ror.org/00s9v1h75

  7. 7 European Medicines Agency, London, United Kingdom
  8. 8 Universidade Do Porto
    info

    Universidade Do Porto

    Oporto, Portugal

    ROR https://ror.org/043pwc612

  9. 9 Health Protection Agency, London, United Kingdom
  10. 10 Medical Products Agency, Uppsala, Sweden
  11. 11 Scientific Unit on Biological Hazards, European Food Safety Authority, Via Carlo Magno 1/A, I-43126 Parma, Italy
  12. 12 Bicêtre Hospital
    info

    Bicêtre Hospital

    Le Kremlin-Bicêtre, Francia

    ROR https://ror.org/05c9p1x46

  13. 13 Hospital Ramón y Cajal
    info

    Hospital Ramón y Cajal

    Madrid, España

    ROR https://ror.org/050eq1942

  14. 14 University of Bern
    info

    University of Bern

    Berna, Suiza

    ROR https://ror.org/02k7v4d05

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Revista:
Clinical Infectious Diseases

ISSN: 1058-4838

Año de publicación: 2013

Volumen: 56

Número: 7

Páginas: 1030-1037

Tipo: Artículo

DOI: 10.1093/CID/CIS1043 SCOPUS: 2-s2.0-84875029941 WoS: WOS:000316167000019 GOOGLE SCHOLAR

Otras publicaciones en: Clinical Infectious Diseases

Resumen

The blaESBL and blaAmpC genes in Enterobacteriaceae are spread by plasmid-mediated integrons, insertion sequences, and transposons, some of which are homologous in bacteria from food animals, foods, and humans. These genes have been frequently identified in Escherichia coli and Salmonella from food animals, the most common being blaCTX-M-1, bla CTX-M-14, and blaCMY-2. Identification of risk factors for their occurrence in food animals is complex. In addition to generic antimicrobial use, cephalosporin usage is an important risk factor for selection and spread of these genes. Extensive international trade of animals is a further risk factor. There are no data on the effectiveness of individual control options in reducing public health risks. A highly effective option would be to stop or restrict cephalosporin usage in food animals. Decreasing total antimicrobial use is also of high priority. Implementation of measures to limit strain dissemination (increasing farm biosecurity, controls in animal trade, and other general postharvest controls) are also important. © The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.