Diastereoselective synthesis of (S)- and (R)-alfa-phenylserine by a sulfinimine-mediated Strecker reaction
- Avenoza, A. 1
- Busto, J.H. 1
- Corzana, F. 1
- Peregrina, J.M. 1
- Sucunza, D. 1
- Zurbano, M.M. 1
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1
Universidad de La Rioja
info
ISSN: 0039-7881
Argitalpen urtea: 2005
Alea: 4
Orrialdeak: 575-578
Mota: Artikulua
Beste argitalpen batzuk: Synthesis (Stuttgart)
Laburpena
A straightforward and efficient diastereoselective synthesis of (S)- and (R)-α-phenylserine is reported. The key step involves an asymmetric Strecker reaction of a chiral N-sulfinyl ketimine, which was obtained from the commercially available 2-hydroxyacetophenone.