Synthesis of enantiopure (aMe)Dip and other a-methylated ß-branched amino acid derivatives
- Avenoza, A. 1
- Busto, J.H. 1
- Cativiela, C. 2
- Peregrina, J.M. 1
- Sucunza, D. 1
- Zurbano, M.M. 1
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1
Universidad de La Rioja
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2
Instituto de Nanociencia y Materiales de Aragón
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ISSN: 0957-4166
Año de publicación: 2003
Volumen: 14
Número: 3
Páginas: 399-405
Tipo: Artículo
beta Ver similares en nube de resultadosOtras publicaciones en: Tetrahedron: Asymmetry
Resumen
This report describes the synthesis of the two enantiomerically pure α-methylated β-branched phenylalanine derivatives, (S)- and (R)-α-methyl-β,β-diphenylalanine - (αMe)Dip - starting from the chiral building blocks (R)- and (S)-N-Boc-N,O-isopropylidene-α-methylserine methyl esters, respectively. The key step involves a double alkylation with a Grignard reagent on an ester group. The use of the same protocol for the preparation of other α-methylated β-branched serine derivatives is also described. © 2003 Elsevier Science Ltd. All rights reserved.