Preparation and synthetic applications of (S)- and (R)-N-Boc-N,O-isopropylidene-alfa-methylserinals: asymmetric synthesis of (S)- and (R)-2-amino-2-methylbutanoic acids (Iva)
- Avenoza, A. 1
- Cativiela, C. 2
- Corzana, F. 1
- Peregrina, J.M. 1
- Zurbano, M.M. 1
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1
Universidad de La Rioja
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2
Universidad de Zaragoza
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ISSN: 0022-3263
Argitalpen urtea: 1999
Alea: 64
Zenbakia: 22
Orrialdeak: 8220-8225
Mota: Artikulua
beta Ver similares en nube de resultadosBeste argitalpen batzuk: Journal of Organic Chemistry
Laburpena
This report describes an efficient and convenient large-scale synthesis procedure for (S)- and (R)-N-Boc-α-methylserinal acetonides (3 and 4) starting from (R)-2-methylglycidol 5. The application of both of these compounds as valuable chiral building blocks in the asymmetric synthesis of α-methylamino acids is also demonstrated by the synthesis of (S)- and (R)- isovalines (Iva) (6 and 7).