Synthesis of exo-3-hydroxy-7-azabicyclo[2.2.1]heptane-1-carboxylic acid, a new conformationally constrained 4-hydroxyproline
- Avenoza, A. 1
- Cativiela, C. 2
- Fernández-Recio, M.A. 1
- Peregrina, J.M. 1
-
1
Universidad de La Rioja
info
-
2
Instituto de Nanociencia y Materiales de Aragón
info
ISSN: 0039-7881
Datum der Publikation: 1997
Ausgabe: 2
Seiten: 165-167
Art: Artikel
Andere Publikationen in: Synthesis (Stuttgart)
Zusammenfassung
A conformationally constrained α-amino-β-hydroxy based upon 4-hydroxyproline has been prepared, starting from an iodooxazine intermediate, by opening of the heterocycle, further intramolecular nucleophilic displacement and subsequent hydrolysis.