Macrolide resistance phenotypes and mechanism of resistance in Streptococcus pyogenes in La Rioja, Spain
- Portillo, A. 1
- Lantero, M. 2
- Gastañares, M.J. 2
- Ruiz-Larrea, F. 1
- Torres, C. 1
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1
Universidad de La Rioja
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2
Hospital San Pedro
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ISSN: 0924-8579
Año de publicación: 1999
Volumen: 13
Número: 2
Páginas: 137-140
Tipo: Artículo
Otras publicaciones en: International Journal of Antimicrobial Agents
Resumen
One hundred and thirty seven consecutive clinical Streptococcus pyogenes isolates were evaluated for macrolide-lincosamide-streptogramin resistance (MLS). Forty of these isolates were resistant to erythromycin (29.2%), 36 of them showed the new M resistance phenotype (erythromycin resistant and clindamycin susceptible) and four isolates had the MLS(B) resistance phenotype (erythromycin and clindamycin resistant). In all 36 isolates with the M resistance phenotype, the mef gene was identified by polymerase chain reaction (PCR). In two of the four S. pyogenes isolates with the MLS(B) phenotype, both ermB and ermTR genes were found; negative results were obtained with the other two isolates which might possess a new mechanism of high level resistance against erythromycin not previously described. In summary, a high rate of erythromycin resistance was found in S. pyogenes isolates and the active efflux pump mediated by the mef gene was the mechanism most frequently involved. Copyright (C) 1999 Elsevier Science B.V.