Improved Supercritical Fluid Extraction of Sulphonamides

  1. Tena, M.T. 1
  2. Luque de Castro, M.D. 1
  3. Valcárcel, M. 1
  1. 1 Universidad de Córdoba
    info

    Universidad de Córdoba

    Córdoba, España

    ROR https://ror.org/05yc77b46

Zeitschrift:
Chromatographia

ISSN: 0009-5893

Datum der Publikation: 1995

Ausgabe: 40

Nummer: 3-4

Seiten: 197-203

Art: Artikel

DOI: 10.1007/BF02272171 SCOPUS: 2-s2.0-0028937499 GOOGLE SCHOLAR

Andere Publikationen in: Chromatographia

Zusammenfassung

Different ways used for enhancing the yield of sulphonamides leached from solid supports are reported. Supercritical CO 2 and methanol-modified CO 2 were used as extractants of the target analytes and the impregnation of the solid sample with buffer, derivatization of the analytes and ion-pair formation were assessed. Only the sulphonamide/tetramethylammonium ion-pairs are quantitatively extracted from the solid supports using pure supercritical CO 2, while the other modifications and the presence of a cosolvent lead to recoveries lower than 30% for most of the analytes. Individual separation/quantitation of the analytes was performed off-line using a liquid chromatograph.