Reversible photocontrol of peptide conformation with a rhodopsin-like photoswitch
- Blanco-Lomas, M. 1
- Samanta, S. 2
- Campos, P.J. 1
- Woolley, G.A. 2
- Sampedro, D. 1
-
1
Universidad de La Rioja
info
-
2
University of Toronto
info
ISSN: 0002-7863
Year of publication: 2012
Volume: 134
Issue: 16
Pages: 6960-6963
Type: Article
beta Ver similares en nube de resultadosMore publications in: Journal of the American Chemical Society
Related Projects
Abstract
Reversible photocontrol of biomolecules requires chromophores that can efficiently undergo large conformational changes upon exposure to wavelengths of light that are compatible with living systems. We designed a benzylidene-pyrroline chromophore that mimics the Schiff base of rhodopsin and can be used to introduce light-switchable intramolecular cross-links in peptides and proteins. This new class of photoswitch undergoes an ∼10 Å change in end-to-end distance upon isomerization and can be used to control the conformation of a target peptide efficiently and reversibly using, alternately, violet (400 nm) and blue (446 nm) light. © 2012 American Chemical Society.