Characterization of a cfr-positive methicillin-resistant Staphylococcus epidermidis strain of the lineage ST22 implicated in a life-threatening human infection

  1. Lozano, C. 1
  2. Ruiz-García, M. 2
  3. Gómez-Sanz, E. 1
  4. López-García, P. 2
  5. Royo-García, G. 2
  6. Zarazaga, M. 1
  7. Torres, C. 1
  1. 1 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  2. 2 Hospital General Universitario de Elche
    info

    Hospital General Universitario de Elche

    Elche, España

    ROR https://ror.org/01jmsem62

Revista:
Diagnostic Microbiology and Infectious Disease

ISSN: 0732-8893

Ano de publicación: 2012

Volume: 73

Número: 4

Páxinas: 380-382

Tipo: Artigo

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DOI: 10.1016/J.DIAGMICROBIO.2012.04.013 SCOPUS: 2-s2.0-84863777606 WoS: WOS:000306624800020 GOOGLE SCHOLAR

Outras publicacións en: Diagnostic Microbiology and Infectious Disease

Proxectos relacionados

Detección y caracterización genética de Staphylococcus aureus resistente a meticilina en distintos ecosistemas: humanos, animales, alimentos y medioambiente. Impicaciones en salud humana.

2009/00204/001

Resumo

The cfr gene was identified in 3 methicillin-resistant Staphylococcus epidermidis (MRSE) isolates of lineage ST22 implicated in a fatal human infection. MRSE isolates displayed an indistinguishable pulsed-field gel electrophoresis profile and SCC. mec type III, and showed a multiresistance phenotype. The presence of cfr, fexA, aac(6')- aph(2'), and dfrS1 genes was confirmed by polymerase chain reaction and sequencing. A mutation in 23S rRNA gene (C2534T) and amino acid changes and/or insertions in L3 and L4 proteins were detected. The cfr and fexA genes were located in a conjugative plasmid of approximately 45 kb and in the chromosome. © 2012 Elsevier Inc.