Characterization of a cfr-positive methicillin-resistant Staphylococcus epidermidis strain of the lineage ST22 implicated in a life-threatening human infection
- Lozano, C. 1
- Ruiz-García, M. 2
- Gómez-Sanz, E. 1
- López-García, P. 2
- Royo-García, G. 2
- Zarazaga, M. 1
- Torres, C. 1
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1
Universidad de La Rioja
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2
Hospital General Universitario de Elche
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ISSN: 0732-8893
Datum der Publikation: 2012
Ausgabe: 73
Nummer: 4
Seiten: 380-382
Art: Artikel
Andere Publikationen in: Diagnostic Microbiology and Infectious Disease
Projekte im Zusammenhang
Zusammenfassung
The cfr gene was identified in 3 methicillin-resistant Staphylococcus epidermidis (MRSE) isolates of lineage ST22 implicated in a fatal human infection. MRSE isolates displayed an indistinguishable pulsed-field gel electrophoresis profile and SCC. mec type III, and showed a multiresistance phenotype. The presence of cfr, fexA, aac(6')- aph(2'), and dfrS1 genes was confirmed by polymerase chain reaction and sequencing. A mutation in 23S rRNA gene (C2534T) and amino acid changes and/or insertions in L3 and L4 proteins were detected. The cfr and fexA genes were located in a conjugative plasmid of approximately 45 kb and in the chromosome. © 2012 Elsevier Inc.