Integron-encoded GES-type extended-spectrum ß-lactamase with increased activity toward aztreonam in Pseudomonas aeruginosa

  1. Poirel, L. 1
  2. Brinas, L. 1
  3. Fortineau, N. 1
  4. Nordmann, P. 1
  1. 1 Service de Bactériologie-Virologie, Hôpital de Bicêtre, Université Paris XI, 94275 K.-Bicêtre, France
  2. 2 Area de Bioquimica y Biologia Molecular, Universidad de la Rioja, 26006 Logrono, Spain
  3. 3 Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du General Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France
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Revista:
Antimicrobial Agents and Chemotherapy

ISSN: 0066-4804

Año de publicación: 2005

Volumen: 49

Número: 8

Páginas: 3593-3597

Tipo: Artículo

DOI: 10.1128/AAC.49.8.3593-3597.2005 PMID: 16048994 SCOPUS: 2-s2.0-23044476531 WoS: WOS:000230950700084 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Antimicrobial Agents and Chemotherapy

Repositorio institucional: lock_openAcceso abierto Editor

Resumen

A Pseudomonas aeruginosa strain expresses an extended-spectrum β-lactamase, GES-9, which differs from GES-1 by a Gly243Ser substitution, is inhibited by clavulanic acid and imipenem, and hydrolyzes aztreonam. The blaGES-9 gene was located inside a class 1 integron structure containing two copies of a novel insertion sequence belonging to the IS1111 family