Integron-encoded GES-type extended-spectrum ß-lactamase with increased activity toward aztreonam in Pseudomonas aeruginosa
- Poirel, L. 1
- Brinas, L. 1
- Fortineau, N. 1
- Nordmann, P. 1
- 1 Service de Bactériologie-Virologie, Hôpital de Bicêtre, Université Paris XI, 94275 K.-Bicêtre, France
- 2 Area de Bioquimica y Biologia Molecular, Universidad de la Rioja, 26006 Logrono, Spain
- 3 Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du General Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France
ISSN: 0066-4804
Argitalpen urtea: 2005
Alea: 49
Zenbakia: 8
Orrialdeak: 3593-3597
Mota: Artikulua
Beste argitalpen batzuk: Antimicrobial Agents and Chemotherapy
Laburpena
A Pseudomonas aeruginosa strain expresses an extended-spectrum β-lactamase, GES-9, which differs from GES-1 by a Gly243Ser substitution, is inhibited by clavulanic acid and imipenem, and hydrolyzes aztreonam. The blaGES-9 gene was located inside a class 1 integron structure containing two copies of a novel insertion sequence belonging to the IS1111 family