Schizotypal traits and psychotic-like experiences during adolescencean update

  1. Eduardo Fonseca Pedrero 1
  2. Martin Debbané 2
  1. 1 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  2. 2 Université de Genève
    info

    Université de Genève

    Ginebra, Suiza

    ROR https://ror.org/01swzsf04

Aldizkaria:
Psicothema

ISSN: 0214-9915

Argitalpen urtea: 2017

Alea: 29

Zenbakia: 1

Orrialdeak: 5-17

Mota: Artikulua

DOI: 10.7334/PSICOTHEMA2016.209 DIALNET GOOGLE SCHOLAR lock_openSarbide irekia editor

Beste argitalpen batzuk: Psicothema

Gordailu instituzionala: lock_openSarbide irekia Editor

Laburpena

Background: The psychosis phenotype is distributed along a severity continuum that ranges from psychological well-being to full-blown psychosis. Schizotypal traits and psychotic-like experiences are considered as one of the possible phenotypic indicators of the latent liability for psychosis (named schizotypy). This selective review offers a general overview and update of trait schizotypy and psychotic like experiences during adolescence. Method: The previous literature on schizotypal traits and psychotic like experiences is selectively reviewed. Results: We begin with a brief introduction of psychosis syndrome from an extended psychosis phenotype framework as well as a brief definition of trait schizotypy and psychotic-like experiences. We introduce the study of these traits and experiences from a developmental perspective, where the psychosis proneness-persistence-impairment model is highlighted. We provide a selective review of the tools available for assessment these constructs from the psychometric high-risk paradigm. We then discuss the factorial validity of the studies conducted in adolescents. In addition, the links between this set of subclinical traits and experiences and other variables gathered from a translational approach are discussed, with the aim to establish a nomological network. Conclusions: We conclude by considering remaining questions and future directions for the understanding of trait schizotypy and psychotic-like experiences during adolescence.

Finantzaketari buruzko informazioa

E.F.P was supported by the Spanish Ministry of Science and Innovation (MICINN), by the Instituto Carlos III, Center for Biomedical Research in the Mental Health Network (CIBERSAM), and by 2015 edition of the BBVA Foundation Grants for Researchers and Cultural Creators (Project references: PSI 2011-28638, PSI 2011-23818 and PSI2014-56114-P). M.D was supported by the Swiss National Science Foundation (100019_159440).

Erreferentzia bibliografikoak

  • Armando, M., Nelson, B., Yung, A. R., Ross, M., Birchwood, M., Girardi, P., & Nastro, P. F. (2010). Psychotic-like experiences and correlation with distress and depressive symptoms in a community sample of adolescents and young adults. Schizophrenia Research, 119, 258- 265.
  • Barragan, M., Laurens, K. R., Blas Navarro, J., & Obiols, J. E. (2011). ‘Theory of Mind’, psychotic-like experiences and psychometric schizotypy in adolescents from the general population. Psychiatry Research, 186, 225-131.
  • Barragan, M., Laurens, K. R., Navarro, J. B., & Obiols, J. E. (2011). Psychotic-like experiences and depressive symptoms in a community sample of adolescents. European Psychiatry, 26, 396-401.
  • Barrantes-Vidal, N., Fañanás, L., Rosa, A., Caparrós, B., Riba, M. D., & Obiols, J. E. (2002). Neurocognitive, behavioral and neurodevelopmental correlates of schizotypy clusters in adolescents from the general population. Schizophrenia Research, 61, 293-302.
  • Barrantes-Vidal, N., Gómez-de-Regil, L., Navarro, B., Vicens-Vilanova, J., Obiols, J., & Kwapil, T. (2013). Psychotic-like symptoms and positive schizotypy are associated with mixed and ambiguous handedness in an adolescent community sample. Psychiatry Research, 30, 188-194.
  • Barrantes-Vidal, N., Grant, P., & Kwapil, T. (2015). The role of schizotypy in the study of the etiology of schizophrenia spectrum disorders. Schizophrenia Bulletin, 41, S408-416.
  • Capra, C., Kavanagh, D., Hides, L., & Scott, J. (2013). Brief screening for psychosis-like experiences. Schizophrenia Research, 149, 104-107.
  • Cella, M., Serra, M., Lai, A., Mason, O. J., Sisti, D., Rocchi, M. B., ..., Petretto, D. R. (2013). Schizotypal traits in adolescents: Links to family history of psychosis and psychological distress. European Psychiatry, 28, 247-253.
  • Cohen, A., Mohr, C., Ettinger, U., Chan, R. C. K., & Park, S. (2015). Schizotypy as an organizing framework for social and affective sciences. Schizophrenia Bulletin, 41, S427-435.
  • Cougnard, A., Marcelis, M., Myin-Germeys, I., De Graaf, R., Vollebergh, W., Krabbendam, L., ..., Van Os, J. (2007). Does normal developmental expression of psychosis combine with environmental risk to cause persistence of psychosis? A psychosis proneness-persistence model. Psychological Medicine, 37, 513-527.
  • Cronbach, L. J., & Meehl, P. E. (1955). Construct validity in psychological tests. Psychological Bulletin, 52, 281-302.
  • Cyhlarova, E., & Claridge, G. (2005). Development of a version of the Schizotypy Traits Questionnaire (STA) for screening children. Schizophrenia Research, 80, 253-261.
  • Dahoun, T., Eliez, S., Chen, F., Badoud, D., Schneider, M., Larøi, F. F., & Debbané, M. (2013). Action simulation in hallucination-prone adolescents. Frontiers in Human Neuroscience, 7, 1-13.
  • De Loore, E., Gunther, N., Drukker, M., Feron, F., Sabbe, B., Deboutte, D., ..., Myin-Germeys, I. (2008). Auditory hallucinations in adolescence: A longitudinal general population study. Schizophrenia Research, 102, 229-230.
  • Debbané, M., Badoud, D., Balanzin, D., & Eliez, S. (2013). Broadly defined risk mental states during adolescence: Disorganization mediates positive schizotypal expression. Schizophrenia Research, 147, 153- 156.
  • Debbané, M., & Barrantes-Vidal, N. (2015). Schizotypy from a developmental perspective. Schizophrenia Bulletin, 41, S386-395.
  • Debbané, M., Eliez, S., Badoud, D., Conus, P., Flückiger, R., & Schultze- Lutter, F. (2015). Developing psychosis and its risk states through the lens of schizotypy. Schizophrenia Bulletin, 41, S396-407.
  • Debbané, M., & Mohr, C. (2015). Integration and development in schizotypy research: an introduction to the special supplement. Schizophrenia Bulletin, 41, Suppl 2, S363-365.
  • Debbané, M., Vrticka, P., Lazouret, M., Badoud, D., Sander, D., & Eliez, S. (2014). Self-reflection and positive schizotypy in the adolescent brain. Schizophrenia Research, 152, 65-72.
  • Dickson, H., Laurens, K. R., Cullen, A. E., & Hodgins, S. (2012). Meta- analyses of cognitive and motor function in youth aged 16 years and younger who subsequently develop schizophrenia. Psychological Medicine, 42, 743-755.
  • DiDuca, D., & Joseph, S. (1999). Assessing schizotypal traits in 13-18 year olds: Revising the JSS. Personality and Individual Differences, 27, 673-682.
  • Dolphin, L., Dooley, B., & Fitzgerald, A. (2015). Prevalence and correlates of psychotic like experiences in a nationally representative community sample of adolescents in Ireland. Schizophrenia Research, 169, 241-217.
  • Domínguez, M. G., Wichers, M., Lieb, R., Wittchen, H.-U., & van Os, J. (2011). Evidence that onset of clinical psychosis is an outcome of progressively more persistent subclinical psychotic experiences: An 8-year cohort study. Schizophrenia Bulletin, 37, 84-93.
  • Downs, J. M., Cullen, A. E., Barragan, M.,& Laurens, K. R.(2013). Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort. Schizophrenia Research, 144, 99-104.
  • Ericson, M., Tuvblad, C., Raine, A., Young-Wolff, K., & Baker, L. A. (2011). Heritability and longitudinal stability of schizotypal traits during adolescence. Behavior Genetics, 41, 499-511.
  • Ettinger, U., Meyhöfer, I., Steffens, M., Wagner, M., & Koutsouleris, N. (2014). Genetics, cognition, and neurobiology of schizotypal personality: A review of the overlap with schizophrenia. Frontiers of Psychiatry, 5, 18.
  • Fisher, H. L., Caspi, A., Poulton, R., Meier, M. H., Houts, R., Harrington, H., ..., Moffitt, T. E. (2013). Specificity of childhood psychotic symptoms for predicting schizophrenia by 38 years of age: A birth cohort study. Psychological Medicine, 43, 2077-2086.
  • Fonseca-Pedrero, E., Debbané, M., Schneider, M., Badoud, D., & Eliez, S. (2016). Schizotypal traits in adolescents with 22q11.2 deletion syndrome: Validity, reliability and risk for psychosis. Psychological Medicine, 46, 1005-1013.
  • Fonseca-Pedrero, E., Gooding, D., Debbané, M., & Muñiz, J. (2016). Psychopathology: Psychosis assessment and high-risk paradigms. In F. T. L. Leong, D. Bartram, F. Cheung, K. F. Geisinger, & D. Iliescu (Eds.), The ITC International Handbook of Testing and Assessment (pp. 147-170). United kingdom: Oxford University Press.
  • Fonseca-Pedrero, E., Gooding, D. C., Ortuño-Sierra, J., & Paino, M. (2016). Assessing self-reported clinical high risk symptoms in community- derived adolescents: A psychometric evaluation of the Prodromal Questionnaire-Brief. Comprehensive Psychiatry, 66, 1-8.
  • Fonseca-Pedrero, E., Lemos-Giráldez, S., Paino, M., & Muñiz, J. (2011). Schizotypy, emotional-behavioural problems and personality disorder traits in a non-clinical adolescent population. Psychiatry Research, 190, 316-321.
  • Fonseca-Pedrero, E., Lemos-Giráldez, S., Paino, M., Villazón-García, U., & Muñiz, J. (2009). Validation of the Schizotypal Personality Questionnaire Brief form in adolescents. Schizophrenia Research, 111, 53-60.
  • Fonseca-Pedrero, E., Ortuño-Sierra, J., Paino, M., Lemos Giraldez, S., & Muñiz, J. (2015). Experiencias esquizotípicas en la adolescencia: propiedades psicométricas del Schizotypal Personality Questionnarie- Child [Schizotypal experiences in adolescence: Psychometric properties of Schizotypal Personality Questionnarie-Child]. Anales de Psicología, 31, 414-421.
  • Fonseca-Pedrero, E., Paino-Piñeiro, M., Lemos-Giráldez, S., Sierra- Baigrie, S., & Muñiz, J. (in press a). Psychotic-like experiences. In J. R. Levesque (Ed.), Encyclopedia of Adolescence (2nd ed.). New York: Springer.
  • Fonseca-Pedrero, E., Paino-Piñeiro, M., Lemos-Giráldez, S., Sierra- Baigrie, S., & Muñiz, J. (in press b). Schizotypy. In J. R. Levesque (Ed.), Encyclopedia of Adolescence (2nd ed.). New York: Springer.
  • Ford, J. M., Morris, S. E., Hoffman, Sommer, I., Waters, F., McCarthy- Jones, S., ..., Cuthbert, B. N. (2014). Studying hallucinations within the NIMH RDoC framework. Schizophrenia Bulletin, 40, S295-S304.
  • Fossati, A., Raine, A., Carretta, I., Leonardi, B., & Maffei, C. (2003). The three-factor model of schizotypal personality: Invariance across age and gender. Personality and Individual Differences, 35, 1007- 1019.
  • Fusar-Poli, P., Carpenter, W. T., Woods, S. W., & McGlashan, T. H. (2014). Attenuated Psychosis Syndrome: Ready for DSM-5.1? Annual Review of Clinical Psychology, 10, 155-192.
  • Fusar-Poli, P., Deste, G., Smieskova, R., Barlati, S., Yung, A. R., Howes, O., ..., Borgwardt, S. (2012). Cognitive functioning in prodromal psychosis: A meta-analysis. Archives of General Psychiatry, 69, 562- 571.
  • Gore, F. M., Bloem, P. J., Patton, G. C., Ferguson, J., Joseph, V., Coffey, C., ..., Mathers, C. D. (2011). Global burden of disease in young people aged 10-24 years: A systematic analysis. Lancet, 18, 2093-2102.
  • Gur, R. C., Calkins, M. E., Satterthwaite, T. D., Ruparel, K., Bilker, W. B., Moore, T. M., ..., Gur, R. (2014). Neurocognitive growth charting in psychosis spectrum youths. JAMA Psychiatry, 71, 366-374.
  • Häfner, H., & An Der Heiden, W. (1999). The course of schizophrenia in the light of modern follow-up studies: The ABC and WHO studies. European Archives of Psychiatry and Clinical Neuroscience, 249, S14-26.
  • Hanssen, M., Krabbendam, L., Vollema, M., Delespaul, P., & Van Os, J. (2006). Evidence for Instrument and Family-Specific Variation of Subclinical Psychosis Dimensions in the General Population. Journal of Abnormal Psychology, 115, 5-14.
  • Hides, L., Lubman, D. I., Buckby, J., Yuen, H. P., Cosgrave, E., Baker, K., & Yung, A. R. (2009). The association between early cannabis use and psychotic-like experiences in a community adolescent sample. Schizophrenia Research, 112, 130-135.
  • Horwood, J., Salvi, G., Thomas, K., Duffy, L., Gunnell, D., Hollis, C., ..., Harrison, G. (2008). IQ and non-clinical psychotic symptoms in 12- year-olds: Results from the ALSPAC birth cohort. British Journal of Psychiatry, 193, 185-191.
  • Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D.S., Quinn, K., Sanislow, C., & Wang, P. (2010). Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders. The American Journal Psychiatry, 167, 748-751.
  • Jones, H. P., Testa, R. R., Ross, N., Seal, M. L., Pantelis, C., & Tonge, B. (2015). The Melbourne assessment of Schizotypy in kids: A useful measure of childhood schizotypal personality disorder. BioMed Research International, 635732.
  • Kahn, R. S., Sommer, I. E., Murray, R. M., Meyer-Lindenberg, A., Weinberger, D. R., Cannon, T. D., ..., Insel, T. R. (2015). Schizophrenia. Nature Reviews Disease Primers, 1, 15067.
  • Kaymaz, N., Drukker, M., Lieb, R., Wittchen, H. U., Werbeloff, N., Weiser, M., ..., van Os, J. (2012). Do subthreshold psychotic experiences predict clinical outcomes in unselected non-help-seeking population-based samples? A systematic review and meta-analysis, enriched with new results. Psychological Medicine, 20, 1-15.
  • Kelleher, I., & Cannon, M. (2011). Psychotic-like experiences in the general population: Characterizing a high-risk group for psychosis. Psychological Medicine, 41, 1-6.
  • Kelleher, I., Cederlöf, M., & Lichtenstein, P. (2014). Psychotic experiences as a predictor of the natural course of suicidal ideation: A Swedish cohort study. World Psychiatry, 13, 184-188.
  • Kelleher, I., Clarke, M. C., Rawdon, C., Murphy, J., & Cannon, M. (2013). Neurocognition in the extended psychosis phenotype: performance of a community sample of adolescents with psychotic symptoms on the MATRICS neurocognitive battery. Schizophrenia Bulletin, 39, 1018- 1026.
  • Kelleher, I., Connor, D., Clarke, M. C., Devlin, N., Harley, M., & Cannon, M. (2012). Prevalence of psychotic symptoms in childhood and adolescence: A systematic review and meta-analysis of population- based studies. Psychological Medicine, 9, 1-7.
  • Kelleher, I., Corcoran, P., Keeley, H., Wigman, J. T., Devlin, N., Ramsay, H., ..., Cannon, M. (2013). Psychotic symptoms and population risk for suicide attempt: A prospective cohort study. JAMA Psychiatry, 70, 940-948.
  • Kelleher, I., Harley, M., Lynch, F., Arseneault, L., Fitzpatrick, C., & Cannon, M. (2008). Associations between childhood trauma, bullying and psychotic symptoms among a school-based adolescent sample. British Journal of Psychiatry, 193, 378-382.
  • Kelleher, I., Harley, M., Murtagh, A., & Cannon, M. (2011). Are screening instruments valid for psychotic-Like experiences? A validation study of screening questions for psychotic-like experiences using in-depth clinical interview. Schizophrenia Bulletin, 37, 362-369.
  • Kelleher, I., Keeley, H., Corcoran, P., Lynch, F., Fitzpatrick, C., Devlin, N., ..., Cannon, M. (2012). Clinicopathological significance of psychotic experiences in non-psychotic young people: Evidence from four population-based studies. British Journal of Psychiatry, 201, 26-32.
  • Kelleher, I., Keeley, H., Corcoran, P., Ramsay, H., Wasserman, C., Carli, V., ..., Cannon, M. (2013). Childhood trauma and psychosis in a prospective cohort study: Cause, effect, and directionality. American Journal of Psychiatry, 170, 734-741.
  • Kendler, K. S., McGuire, M., Gruenberg, A. M., O’Hare, A., Spellman, M., & Walsh, D. (1993). The Roscommon family study: I. Methods, diagnosis of probands, and risk of schizophrenia in relatives. Archives of General Psychiatry, 50, 527-540.
  • Kwapil, T. R., & Barrantes-Vidal, N. (2015). Schizotypy: Looking back and moving forward. Schizophrenia Bulletin, 41, S366-373.
  • Kobayashi, H., Nemoto, T., Koshikawa, H., Osono, Y., Yamazawa, R., Murakami, M., …, Mizuno, M. (2008). A self-reported instrument for prodromal symptoms of psychosis: Testing the clinical validity of the PRIME Screen-Revised (PS-R) in a Japanese population. Schizophrenia Research, 106, 356-362.
  • Lee, K. W., Chan, K. W., Chang, W. C., Lee, E. H., Hui, C. L., & Chen, E. Y. (2016). A systematic review on definitions and assessments of psychotic-like experiences. Early Intervention in Psychiatry, 10, 3-16.
  • Lee, Y. J., Cho, S. J., Cho, I. H., Jang, J. H., & Kim, S. J. (2012). The relationship between psychotic-like experiences and sleep disturbances in adolescents. Sleep Medicine, 13, 1021-1027.
  • Lemos Giráldez, S., Fonseca-Pedrero, E., Paino, M., & Vallina, O. (2015). Esquizofrenia y otros trastornos psicóticos [Schizophrenia and others psychotic disorders]. Madrid: Síntesis.
  • Lenzenweger, M. F. (2010). Schizotypy and schizophrenia: The view from experimental psychopathology. New York: Guilford Press.
  • Lenzenweger, M. F. (2015). Thinking clearly about schizotypy: Hewing to the schizophrenia liability core, considering interesting tangents, and avoiding conceptual quicksand. Schizophrenia Bulletin, 41, S483-491.
  • Liddle, P. F. (1987). The symptoms of chronic schizophrenia. A re- examination of the positive-negative dichotomy. British Journal of Psychiatry, 151, 145-151.
  • Linney, Y. M., Murray, R. M., Peters, E. R., MacDonald, A. M., Rijsdijk, F., & Sham, P. C. (2003). A quantitative genetic analysis of schizotypal personality traits. Psychological Medicine, 33, 803-816.
  • Linscott, R. J., & van Os, J. (2013). An updated and conservative systematic review and meta-analysis of epidemiological evidence on psychotic experiences in children and adults: On the pathway from proneness to persistence to dimensional expression across mental disorders. Psychological Medicine, 43, 1133-1149.
  • Mark, W., & Toulopoulou, T. (2016). Psychometric properties of “Community Assessment of Psychic Experiences”: Review and meta- analyses. Schizophrenia Bulletin, 42, 34-44.
  • Mass, R., Haasen, C., & Borgart, E. J. (2005). Abnormal subjective experiences of schizophrenia: Evaluation of the Eppendorf Schizophrenia Inventory. Psychiatry Research, 135, 91-101.
  • McGrath, J. J., Saha, S., Al-Hamzawi, A., Alonso, J., Bromet, E. J., Bruffaerts, R., ..., Kessler, R. C. (2015). Psychotic experiences in the general population: A cross-national analysis based on 31,261 respondents from 18 countries. JAMA Psychiatry, 72, 697-705.
  • Meehl, P. E. (1962). Schizotaxia, schizotypy, schizophrenia. American Psychologist, 17, 827-838.
  • Miller T. J., Cicchetti D., Markovich P. J., McGlashan T. H., & Wood S. W. (2004). The SIPS screen: A brief self-report screen to detect the schizophrenia prodrome. Schizophrenia Research, 70, S78.
  • Nelson, M. T., Seal, M. L., Pantelis, C., & Phillips, L. J. (2013). Evidence of a dimensional relationship between schizotypy and schizophrenia: A systematic review. Neuroscience & Biobehavioral Reviews, 37, 317- 327.
  • Nuevo, R., Chatterji, S., Verdes, E., Naidoo, N., Arango, C., & Ayuso- Mateos, J. L. (2012). The continuum of psychotic symptoms in the general population: A cross-national study. Schizophrenia Bulletin, 38, 475-485.
  • Núñez, D., Arias, V., Vogel, E., & Gómez, L. (2015). Internal structure of the Community Assessment of Psychic Experiences-Positive (CAPE- P15) scale: Evidence for a general factor. Schizophrenia Research, 165, 236-242.
  • Olesen, J., Gustavsson, A., Svensson, M., Wittchen, H. U., & Jönsson, B. (2012). The economic cost of brain disorders in Europe. European Journal of Neurology, 19, 155-162.
  • Oorschot, M., Kwapil, T., Delespaul, P., & Myin-Germeys, I. (2009). Momentary assessment research in psychosis. Psychological Assessment, 21, 498-505.
  • Ortuño-Sierra, J., Badoud, D., Knecht, F., Paino, M., Eliez, S., Fonseca- Pedrero, E., & Debbané, M. (2013). Testing measurement invariance of the Schizotypal Personality Questionnaire-Brief scores across Spanish and Swiss adolescents. PLoS One, 8(12), e82041.
  • Perälä, J., Suvisaari, J., Saarni, S. I., Kuoppasalmi, K., Isometsä, E., Pirkola, S., ..., Lönnqvist, J. (2007). Lifetime prevalence of psychotic and bipolar I disorders in a general population. Archives of General Psychiatry, 64, 19-28.
  • Poulton, R., Caspi, A., Moffitt, T. E., Cannon, M., Murray, R., & Harrington, H. (2000). Children’s self-reported psychotic symptoms and adult schizophreniform disorder: A 15-year longitudinal study. Archives of General Psychiatry, 57, 1053-1058.
  • Raine, A., Fung, A. L., & Lam, B. Y. (2011). Peer victimization partially mediates the schizotypy-aggression relationship in children and adolescents. Schizophrenia Bulletin, 37, 937-945.
  • Rawdon, C., Murphy, J., Blanchard, M. M., Kelleher, I., Clarke, M. C., Kavanagh, F., ..., Roche, R. A. (2013). Reduced P300 amplitude during retrieval on a spatial working memory task in a community sample of adolescents who report psychotic symptoms. BMC Psychiatry, 13, 125.
  • Rawlings, D., & MacFarlane, C. (1994). A multidimensional schizotypal traits questionnaire for young adolescents. Personality and Individual Differences, 17, 489-496.
  • Roddy, S., Tiedt, L., Kelleher, I., Clarke, M. C., Murphy, J., Rawdon, C., ..., Cannon, M. (2012). Facial emotion recognition in adolescents with psychotic-like experiences: A school-based sample from the general population. Psychological Medicine, 42, 2157-2166.
  • Ronald, A. (2015). Recent quantitative genetic research on psychotic experiences: New approaches to old questions. Current Opinion in Behavioral Sciences, 2, 81-88.
  • Ronald, A., Sieradzka, D., Cardno, A. G., Haworth, C. M., McGuire, P., & Freeman, D. (2014). Characterization of psychotic experiences in adolescence using the specific psychotic experiences questionnaire: Findings from a study of 5000 16-year-old twins. Schizophrenia Bulletin, 40, 868-877.
  • Satterthwaite, T. D., Vandekar, S. N., Wolf, D. H., Bassett, D. S., Ruparel, K., Shehzad, Z., ..., Gur, R. E. (2015). Connectome-wide network analysis of youth with psychosis-spectrum symptoms. Molecular Psychiatry, 20, 1508-1015.
  • Satterthwaite, T. D., Wolf, D. H., Calkins, M. E., Vandekar, S. N., Erus, G., Ruparel, K., ..., Gur, R. E. (2016). Structural brain abnormalities in youth with psychosis spectrum symptoms. JAMA Psychiatry, 73, 515-524.
  • Sieradzka, D., Power, R. A., Freeman, D., Cardno, A. G., Dudbridge, F., & Ronald, A. (2015). Heritability of individual psychotic experiences captured by common genetic variants in a community sample of adolescents. Behavior Genetics, 45, 493-502.
  • Sieradzka, D., Power, R. A., Freeman, D., Cardno, A. G., McGuire, P., Plomin, R., ..., Ronald, A. (2014). Are genetic risk factors for psychosis also associated with dimension-specific psychotic experiences in adolescence? PLoS One, 9 e94398.
  • Stafford, M. R., Jackson, H., Mayo-Wilson, E., Morrison, A. P., & Kendall, T. (2013). Early interventions to prevent psychosis: Systematic review and meta-analysis. British Medical Journal, 346, f185.
  • Stefanis, N. C., Hanssen, M., Smirnis, N. K., Avramopoulos, D. A., Evdokimidis, I. K., Stefanis, C. N., ..., Van Os, J. (2002). Evidence that three dimensions of psychosis have a distribution in the general population. Psychological Medicine, 32, 347-358.
  • van Os, J., Kenis, G., & Rutten, B. P. (2010). The environment and schizophrenia. Nature, 468, 203-312.
  • van Os, J., Linscott, R. J., Myin-Germeys, I., Delespaul, P., & Krabbendam, L. (2009). A systematic review and meta-analysis of the psychosis continuum: Evidence for a psychosis proneness-persistence- impairment model of psychotic disorder. Psychological Medicine, 39, 179-195.
  • Walker, E., & Bollini, A. (2002). Pubertal neurodevelopmental and the emergence of psychotic symptons. Schizophrenia Research, 54, 17- 23.
  • Welham, J., Scott, J., Williams, G., Najman, J., Bor, W., O’Callaghan, M., & McGrath, J. (2009). Emotional and behavioural antecedents of young adults who screen positive for non-affective psychosis: A 21- year birth cohort study. Psychological Medicine, 39, 625-634.
  • Werbeloff, N., Drukker, M., Dohrenwend, B. P., Levav, I., Yoffe, R., van Os, J., ..., Weiser, M. (2012). Self-reported attenuated psychotic symptoms as forerunners of severe mental disorders later in life. Archives of General Psychiatry, 69, 467-475.
  • Wigman, J. T., Vollebergh, W. A., Raaijmakers, Q. A., Iedema, J., van Dorsselaer, S., Ormel, J., ..., van Os, J. (2011). The structure of the extended psychosis phenotype in early adolescence. A cross-sample replication. Schizophrenia Bulletin, 37, 850-860.
  • Wolf, D. H., Satterthwaite, T. D., Calkins, M. E., Ruparel, K., Elliott, M. A., Hopson, R. D., ..., Gur, R. E. (2015). Functional neuroimaging abnormalities in youth with psychosis spectrum symptoms. JAMA Psychiatry, 72, 456-465.
  • Yung, A. R., Buckby, J. A., Cotton, S. M., Cosgrave, E. M., Killackey, E. J., Stanford, C., ..., McGorry, P. D. (2006). Psychotic-like experiences in nonpsychotic help-seekers: Associations with distress, depression, and disability. Schizophrenia Bulletin, 32, 352-359.
  • Yung, A. R., Nelson, B., Baker, K., Buckby, J. A., Baksheev, G., & Cosgrave, E. M. (2009). Psychotic-like experiences in a community sample of adolescents: Implications for the continuum model of psychosis and prediction of schizophrenia. Australian and New Zealand Journal of Psychiatry, 43, 118-128.
  • Yung, A. R., Stanford, C., Cosgrave, E., Killackey, E., Phillips, L., Nelson, B., & McGorry, P. D. (2006). Testing the Ultra High Risk (prodromal) criteria for the prediction of psychosis in a clinical sample of young people. Schizophrenia Research, 84, 57-66.
  • Zammit, S., Hamshere, M., Dwyer, S., Georgiva, L., Timpson, N., Moskvina, V., ..., O’Donovan, M. C. (2014). A population-based study of genetic variation and psychotic experiences in adolescents. Schizophrenia Bulletin, 40, 1254-1262.
  • Zammit, S., Kounali, D., Cannon, M., David, A. S., Gunnell, D., Heron, J., ..., Lewis, G. (2013). Psychotic experiences and psychotic disorders at age 18 in relation to psychotic experiences at age 12 in a longitudinal population-based cohort study. American Journal of Psychiatry, 170, 742-750.
  • Zammit, S., Owen, M. J., Evans, J., Heron, J., & Lewis, G. (2011). Cannabis, COMT and psychotic experiences. British Journal of Psychiatry, 199, 380-385.
  • Zavos, H. M., Freeman, D., Haworth, C. M., McGuire, P., Plomin, R., Cardno, A. G., & Ronald, A. (2014). Consistent etiology of severe, frequent psychotic experiences and milder, less frequent manifestations: A twin study of specific psychotic experiences in adolescence. JAMA Psychiatry, 71, 1049-1057.
  • Mason, O. (2015). The assessment of schizotypy and its clinical relevance. Schizophrenia Bulletin, 41, S374-385.
  • Fonseca-Pedrero, E., Muñiz, J., Lemos-Giráldez, S., Paino, M., & Villazón-García, U. (2010). ESQUIZO-Q: Cuestionario Oviedo para la Evaluación de la Esquizotipia [ESQUIZO-Q: Oviedo Questionnaire for Schizotypy Assessment]. Madrid: TEA ediciones.
  • Calkins, M. E., Moore, T. M., Merikangas, K. R., Burstein, M., Satterthwaite, T. D., Bilker, W. B., ..., Gur, R. E. (2014). The psychosis spectrum in a young U.S. community sample: findings from the Philadelphia Neurodevelopmental Cohort. World Psychiatry, 13, 296-305.