Química
Departamento
Helena
Coelho
Publicaciones en las que colabora con Helena Coelho (16)
2023
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Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b
Nature Communications, Vol. 14, Núm. 1
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Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody
JACS Au, Vol. 3, Núm. 1, pp. 204-215
2022
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Structural basis for the synthesis of the core 1 structure by C1GalT1
Nature Communications, Vol. 13, Núm. 1
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Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody
Journal of the American Chemical Society
2021
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Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen
Biochemistry, Vol. 60, Núm. 17, pp. 1327-1336
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Structural Insights into the Molecular Recognition Mechanism of the Cancer and Pathogenic Epitope, LacdiNAc by Immune-Related Lectins
Chemistry - A European Journal, Vol. 27, Núm. 29, pp. 7951-7958
2020
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Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3
Nature Chemical Biology, Vol. 16, Núm. 3, pp. 351-360
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Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins
Angewandte Chemie - International Edition, Vol. 59, Núm. 52, pp. 23763-23771
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Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody
Chemical Communications, Vol. 56, Núm. 96, pp. 15137-15140
2019
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The Plasticity of the Carbohydrate Recognition Domain Dictates the Exquisite Mechanism of Binding of Human Macrophage Galactose-Type Lectin
Chemistry - A European Journal, Vol. 25, Núm. 61, pp. 13945-13955
2018
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Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts
Chemistry - A European Journal, Vol. 24, Núm. 33, pp. 8382-8392
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Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4
ACS Central Science, Vol. 4, Núm. 9, pp. 1274-1290
2017
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The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences
Nature Communications, Vol. 8, Núm. 1
2015
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Detection of tumor-associated glycopeptides by Lectins: The peptide context modulates carbohydrate recognition
ACS chemical biology, Vol. 10, Núm. 3, pp. 747-756
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The Quest for Anticancer Vaccines: Deciphering the Fine-Epitope Specificity of Cancer-Related Monoclonal Antibodies by Combining Microarray Screening and Saturation Transfer Difference NMR
Journal of the American Chemical Society, Vol. 137, Núm. 39, pp. 12438-12441
2014
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Delineating binding modes of Gal/GalNAc and structural elements of the molecular recognition of tumor-associated mucin glycopeptides by the human macrophage galactose-type lectin
Chemistry - A European Journal, Vol. 20, Núm. 49, pp. 16147-16155