Ismael
Compañón Pérez
Investigador en el periodo 2014-2022
Henrik
Clausen
Publicaciones en las que colabora con Henrik Clausen (10)
2024
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A family of di-glutamate mucin-degrading enzymes that bridges glycan hydrolases and peptidases
Nature Catalysis, Vol. 7, Núm. 4, pp. 386-400
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Rational Design of Dual-Domain Binding Inhibitors for N-Acetylgalactosamine Transferase 2 with Improved Selectivity over the T1 and T3 Isoforms
JACS Au, Vol. 4, Núm. 9, pp. 3649-3656
2022
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Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut
Nature Communications, Vol. 13, Núm. 1
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Structural basis for the synthesis of the core 1 structure by C1GalT1
Nature Communications, Vol. 13, Núm. 1
2020
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Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3
Nature Chemical Biology, Vol. 16, Núm. 3, pp. 351-360
2018
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Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts
Chemistry - A European Journal, Vol. 24, Núm. 33, pp. 8382-8392
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Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4
ACS Central Science, Vol. 4, Núm. 9, pp. 1274-1290
2017
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The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences
Nature Communications, Vol. 8, Núm. 1
2015
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Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation
Nature Communications, Vol. 6, pp. 1-12
2014
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Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase 2
Angewandte Chemie International, Vol. 53, Núm. 31, pp. 8206-8210