Ismael
Compañón Pérez
Investigador en el periodo 2014-2022
Ramón
Hurtado Guerrero
Publicaciones en las que colabora con Ramón Hurtado Guerrero (22)
2024
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A family of di-glutamate mucin-degrading enzymes that bridges glycan hydrolases and peptidases
Nature Catalysis, Vol. 7, Núm. 4, pp. 386-400
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Correction to: Molecular basis for bacterial N-glycosylation by a soluble HMW1C-like N-glycosyltransferase (Nature Communications, (2023), 14, 1, (5785), 10.1038/s41467-023-41238-1)
Nature Communications
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Rational Design of Dual-Domain Binding Inhibitors for N-Acetylgalactosamine Transferase 2 with Improved Selectivity over the T1 and T3 Isoforms
JACS Au, Vol. 4, Núm. 9, pp. 3649-3656
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Structure-Guided Approach for the Development of MUC1-Glycopeptide-Based Cancer Vaccines with Predictable Responses
JACS Au, Vol. 4, Núm. 1, pp. 150-163
2023
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Molecular basis for bacterial N-glycosylation by a soluble HMW1C-like N-glycosyltransferase
Nature Communications, Vol. 14, Núm. 1
2022
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Atomic and Specificity Details of Mucin 1 O-Glycosylation Process by Multiple Polypeptide GalNAc-Transferase Isoforms Unveiled by NMR and Molecular Modeling
JACS AU, Vol. 2, Núm. 3, pp. 631-645
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Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut
Nature Communications, Vol. 13, Núm. 1
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Structural basis for the synthesis of the core 1 structure by C1GalT1
Nature Communications, Vol. 13, Núm. 1
2020
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Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3
Nature Chemical Biology, Vol. 16, Núm. 3, pp. 351-360
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Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody
Chemical Communications, Vol. 56, Núm. 96, pp. 15137-15140
2019
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Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage
Journal of the American Chemical Society, Vol. 141, Núm. 9, pp. 4063-4072
2018
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Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts
Chemistry - A European Journal, Vol. 24, Núm. 33, pp. 8382-8392
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Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4
ACS Central Science, Vol. 4, Núm. 9, pp. 1274-1290
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The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies inpatients with cancer
29th International Carbohydrate Symposium - ICS2018
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Water Sculpts the Distinctive Shapes and Dynamics of the Tumor-Associated Carbohydrate Tn Antigens: Implications for Their Molecular Recognition
Journal of the American Chemical Society, Vol. 140, Núm. 31, pp. 9952-9960
2017
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The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer
Journal of the American Chemical Society, Vol. 139, Núm. 50, pp. 18255-18261
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The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences
Nature Communications, Vol. 8, Núm. 1
2016
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Design of α-S-Neoglycopeptides Derived from MUC1 with a Flexible and Solvent-Exposed Sugar Moiety
Journal of Organic Chemistry, Vol. 81, Núm. 14, pp. 5929-5941
2015
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Deciphering the Non-Equivalence of Serine and Threonine O-glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti-MUC1 Antibody
Angewandte Chemie International, Vol. 54, Núm. 34, pp. 9830
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Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation
Nature Communications, Vol. 6, pp. 1-12