Francisco
Corzana López
CATEDRÁTICO DE UNIVERSIDAD
University of Cambridge
Cambridge, Reino UnidoPublicaciones en colaboración con investigadores/as de University of Cambridge (41)
2024
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Non-natural MUC1 Glycopeptide Homogeneous Cancer Vaccine with Enhanced Immunogenicity and Therapeutic Activity
XXIX RSEQ Biennial Meeting in Organic Chemistry: Santa Cruz de Tenerife, June 26-28, 2024: Abstract Book
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Non‐natural MUC1 Glycopeptide Homogeneous Cancer Vaccine with Enhanced Immunogenicity and Therapeutic Activity
Angewandte Chemie International Edition
2023
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Methyl-to-Ethyl Replacement Makes the Difference: Structure-Guided Design of a New Cancer Vaccine Based on a Tn An-gen Surrogate
VI RSEQ Chemical Biology Group Meeting - ChemBio VI
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Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules
ACS Central Science, Vol. 9, Núm. 5, pp. 892-904
2022
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New bioorthogonal self-immolative linker based on the Grob fragmentation reaction
XXVIII Reunión Bienal GEQOR (Grupo Especializado de Química Orgánica). Libro de abstracts
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Platform for Orthogonal N-Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents
Journal of the American Chemical Society, Vol. 144, Núm. 23, pp. 10396-10406
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Selective Inhibition of Bruton’s Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors
ACS Pharmacology and Translational Science, Vol. 5, Núm. 11, pp. 1156-1168
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Single Mutation on Trastuzumab Modulates the Stability of Antibody-Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry
Journal of the American Chemical Society, Vol. 144, Núm. 12, pp. 5284-5294
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Synthesis and study of a new bioorthogonal self-immolative linker based on the Grob fragmentation reaction
XXXVIII Reunión Bienal de la Real Sociedad Española de Química - RSEQ 2022 (Abstracts book)
2021
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Accelerating Reaction Rates of Biomolecules by Using Shear Stress in Artificial Capillary Systems
Journal of the American Chemical Society, Vol. 143, Núm. 40, pp. 16401-16410
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Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression
ACS Central Science, Vol. 7, Núm. 5, pp. 868-881
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Arylethynyltrifluoroborate Dienophiles for on Demand Activation of IEDDA Reactions
Bioconjugate Chemistry, Vol. 32, Núm. 8, pp. 1812-1822
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Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation
Organic Letters, Vol. 23, Núm. 21, pp. 8580-8584
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Dichloro Butenediamides as Irreversible Site-Selective Protein Conjugation Reagent
Angewandte Chemie - International Edition, Vol. 60, Núm. 44, pp. 23750-23755
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Effect of Lys-207 of trastuzumab on stability of antibody-drug conjugates bearing linkers based on acetals and thiol-maleimide chemistry
XI Jornada de Química CISQ
2020
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Acetals as acid-sensitive clevable linkers for the design of antibody-drug conjugates
V Chemical Biology Group Meeting (V GEQB)
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Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects
Cell Metabolism, Vol. 31, Núm. 6, pp. 1120-1135.e7
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Precise protein conjugation technology for the construction of homogenous glycovaccines
Drug Discovery Today: Technologies, Vol. 38, pp. 69-75
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Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation
Angewandte Chemie - International Edition, Vol. 59, Núm. 15, pp. 6196-6200
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Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors
RSC Chemical Biology, Vol. 1, Núm. 4, pp. 251-262