Francisco
Corzana López
CATEDRÁTICO DE UNIVERSIDAD
Instituto de Química Física Rocasolano
Madrid, EspañaPublicaciones en colaboración con investigadores/as de Instituto de Química Física Rocasolano (13)
2022
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Binding-driven reactivity attenuation enables NMR identification of selective drug candidates for nucleic acid targets
Communications Chemistry, Vol. 5, Núm. 1
2021
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De Novo Design of Selective Quadruplex-Duplex Junction Ligands and Structural Characterisation of Their Binding Mode: Targeting the G4 Hot-Spot
Chemistry (Weinheim an der Bergstrasse, Germany), Vol. 27, Núm. 20, pp. 6204-6212
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De Novo Design of Selective Quadruplex–Duplex Junction Ligands and Structural Characterisation of Their Binding Mode: Targeting the G4 Hot-Spot
Chemistry - A European Journal
2016
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Finding the Right Candidate for the Right Position: A Fast NMR-Assisted Combinatorial Method for Optimizing Nucleic Acids Binders
Journal of the American Chemical Society, Vol. 138, Núm. 20, pp. 6463-6474
2013
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A dynamic combinatorial approach for the analysis of weak carbohydrate/aromatic complexes: Dissecting facial selectivity in CH/π stacking interactions
Journal of the American Chemical Society, Vol. 135, Núm. 9, pp. 3347-3350
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Chemical interrogation of drug/RNA complexes: From chemical reactivity to drug design
Angewandte Chemie International, Vol. 52, Núm. 11, pp. 3148-3151
2010
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Role of Aromatic Rings in the Molecular Recognition of Aminoglycoside Antibiotics: Implications for Drug Design
Journal of the American Chemical Society, Vol. 132, Núm. 34, pp. 12074-12090
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Structural-based Design of Highly Crowded Ribostamycin/Kanamycin Hybrids as a new Family of Antibiotics
Chemistry - A European Journal, Vol. 16, Núm. 10, pp. 2986-2991
2009
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Role of conserved Salt bridges in homeodomain stability and DNA binding
Journal of Biological Chemistry (Print), Vol. 284, Núm. 35, pp. 23765-23779
2008
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NMR-Based Analysis of Aminoglycoside Recognition by the Resistance Enzyme ANT(4′): The Pattern of OH/NH3+ Substitution Determines the Preferred Antibiotic Binding Mode and is Critical for Drug Inactivation
Journal of the American Chemical Society, Vol. 130, Núm. 15, pp. 5086-5103
2007
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A simple NMR analysis of the protonation equilibrium that accompanies aminoglycoside recognition. Dramatic alterations in neomycin-B protonation state upon binding to a 23-mer RNA aptamer
Chemical Communications, Vol. 2, Núm. 2, pp. 174-176
2006
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Exploring the use of conformationally locked aminoglycosides as a new strategy to overcome bacterial resistance
Journal of the American Chemical Society, Vol. 128, Núm. 1, pp. 100-116
2005
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Molecular recognition of aminoglycoside antibiotics by bacterial defense proteins: NMR study of the structural and conformational features of streptomycin inactivation by bacillus subtilis Aminoglycoside-6-adenyl Transferase
Chemistry - A European Journal, Vol. 11, Núm. 17, pp. 5102-5113